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Blood, Vol. 112, Issue 3, 551-559, August 1, 2008
Lack of nuclear factor- B2/p100 causes a RelB-dependent block in early B lymphopoiesis
Blood Guo et al.
112: 551
Supplemental materials for: Guo et al
Files in this Data Supplement:
- Document 1. Supplemental materials and methods (PDF, 108 KB)
- Figure S1. B-cell subpopulations (JPG, 35 KB)
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(A) Absolute numbers of B-cell subpopulations per 106 bone marrow cells from wild-type and p100−/− mice are shown. (B) Frequency of apoptosis among B-cell subpopulations in wild-type and p100−/− bone marrow was assessed by Annexin-V staining. Bars are representative of 5 mice analyzed at 3 weeks of age.
- Figure S2. Altered NF-κB activity in p100−/− B cells (JPG, 34.7 KB)
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Nuclear extracts from sorted wild-type, p100−/−, p100−/−relB−/+, and p100−/−relB−/− splenic B220+ cells were analyzed for p65/RelA, p50, c-Rel, p52, and RelB DNA-binding activity using the TransAM NF-κB family kit.
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