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Blood, Vol. 111, Issue 12, 5694-5703, June 15, 2008 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils Blood Munitz et al. 111: 5694 Supplemental materials for: Munitz et al Files in this Data Supplement: Figure S1. Expression of PIR-B was assessed by gene chip analysis in CC10–IL-13 inducible transgenic mice that were either supplemented with doxycycline (Dox) or no doxycycline (No Dox) food (JPG, 61.6 KB) - Following 4 weeks of feeding, the lungs (A) and esophagus were harvested for and RNA was collected; **p < 0.01 when comparing Dox and No Dox treated mice. Figure S2. Representative photomicrograph of MBP-stained sections obtained from baseline wild type (WT) and Pirb−/− esophagus (A–B) and small intestine (C–D) (magnification ×100) (JPG, 61 KB) - Eosinophils are identified as dark-brown/black stained cells. LP – lamina propria, Ep – epithelium, L – lumen. Figure S3. Chemotaxis was assessed in thioglycolate elicited neutrophils obtained from wild type (WT) or Pirb−/− mice using a transwell-chamber system in response to LTB4 recombinant mouse MIP-1α (1-100 ng/ml) for 180 min (JPG, 54.3 KB) - Data are expressed as mean fold increase over baseline chemotaxis and are representative of n = 4. Figure S4. PIR–B-kinase complexes were assessed utilizing an antibody-coated membrane (JPG, 86.7 KB) - A representative membrane map (A) and the baseline phosphorylation of a pattern of the PIR–B-kinase complex are shown (B). Densitometric analysis of the baseline phoshphorylation pattern is shown (C). This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

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