|
|
Blood, Vol. 112, Issue 3, 782-792, August 1, 2008
BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgVH unmutated chronic lymphocytic leukemia (CLL) cells
Blood Guarini et al.
112: 782
Supplemental materials for: Guarini et al
Files in this Data Supplement:
- Table S1. Detailed description of the analyses performed for each CLL sample (PDF, 22.8 KB)
- Figure S1. Identification of 71 differentially expressed genes between stimulated (S) and unstimulated (US) cases (JPG, 65.9 KB)
-
This analysis reveals the presence of 2 clusters that mostly reflects the IgVH mutational status: while the majority of IgVH mutated cases do no exert changes upon stimulation, in the IgVH unmutated cases it is possible to observe changes between S and US samples.
- Figure S2. Identification of 6 genes (EGR3, NR4A1, DUSP4, LRMP, CD39, and an unknown sequence) differentially expressed in 2 IgVH unmutated cases after 6 hours of stimulation (JPG, 13.6 KB)
-
The same genes are upregulated also at 24 hour.
- Figure S3. IgM expression evaluated by gene expression profile in CLL samples (JPG, 42.5 KB)
-
|
|
