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Blood, Vol. 113, Issue 19, 4790-4798, May 7, 2009
Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors
Blood Liuba et al.
113: 4790
Supplemental materials for: Liuba et al
Files in this Data Supplement:
- Table S1. Summary of overall survival and engraftment outcome after IUHCT (PDF, 16.4 KB) -
Summary of survival and engraftment frequencies of all fetal mice transplanted at embryonal day E14–16 with whole BM, LMPPs or HSCs. Engraftment was evaluated at 3–4 weeks postnatally. No statistically significant differences were observed between the groups with regard to ratios of surviving and engrafted mice (Fisher’s exact test). (na = not applicable).
- Figure S1. FACS analysis of peripheral blood reconstitution in fetally transplanted X-SCID mice (JPG, 152 KB)
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Representative FACS profiles of peripheral blood analysis from mice transplanted with 200 LMPPs or 200 LTHSCs and analyzed at (A) 4 weeks, (B) 6 weeks, (C) 16 weeks, and (D) 36 weeks after transplantation. Analysis is shown from representative mice transplanted with LMPPs (left) and HSCs (right) analyzed over time. Cells gated on CD45.1 (donor) and CD45.2 (host) populations were analyzed for B220 (B-cell), CD4 and CD8 (T-cell) and Mac-1 (myeloid) expression. Numbers in panels indicate mean percentage of B, T, and myeloid cells of total (donor and recipient) blood cells. Detection level 0.1%.
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