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Blood, Vol. 112, Issue 5, 1750-1758, September 1, 2008
Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists
Blood Wynn et al.
112: 1750
Supplemental materials for: Wynn et al
Files in this Data Supplement:
- Figure S1. TLR4 (LPS) treatment significantly increases reactive oxygen species production (JPG, 61.7 KB)
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Top of figure shows scatter plots gated on living cells from murine neonatal peritoneal washes and further gated on GR-1+Ly6ClowCD11bhigh neutrophils following sham (normal saline) or TLR4 (LPS) pretreatment obtained at 2 hours after cecal slurry administration. Bottom of figure shows reactive oxygen species production as measured using DHR for respective scatter plots shown above. Average MFI for DHR+ PMNs LPS-89905, average MFI for DHR+ PMNs following NS-195. Figure is representative of three separate experiments.
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