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Blood, Vol. 111, Issue 10, 5078-5085, May 15, 2008
MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia
Blood Jongen-Lavrencic et al.
111: 5078
Supplemental materials for: Jongen-Lavrencic et al
Files in this Data Supplement:
- Table S1. Absolute numbers and frequency (%) of specimens with known cytogenetic and molecular abnormalities within the clusters (#) as identified by unsupervised clustering (PDF, 40.1 KB)
- Table S2. The most discriminating microRNAs (up- and downregulated), their score and fold change in expression, chromosome localization (PDF, 215 KB) -
Determined by SAM method for subsets of AML characterized by cytogenetic and molecular abnormalities and normal bone marrow CD34+ cells (BM CD34+).
- Table S3. microRNAs and probe sets (mRNA) included in class predictors of AMLs with (cyto)genetic abnormalities identified by PAM (PDF, 34 KB)
- Figure S1. Measurement of microRNA expression levels (Ct values) using Real Time-RT-PCR is highly reproducible (JPG, 137 KB)
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Four AML samples presented here show high correlation coefficient (R=0.97 to 0.99) when comparing microRNA expression levels in two independent experiments.
- Figure S2. Expression levels (Ct values) of endogenous controls ie small nuclear RNAs (RNU 24, 43, 48, 66) in all 215 AML samples of the cohort (JPG, 85.1 KB)
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Geometric mean of these four RNUs was used for internal normalization.
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