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Blood, Vol. 113, Issue 1, 137-148, January 1, 2009
Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances
Blood Cheung et al.
113: 137
Supplemental materials for: Cheung et al
Files in this Data Supplement:
- Figure S1. A representative array CGH profile of a diagnostic FL case (JPG, 191 KB)
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Array CGH data of an individual with diagnostic FL were presented. The number under each ideogram represents the number of the chromosome. The data were visualized using publicly available software called “SeeGH.” Each data point represents a BAC clone and bars to the left and right represent log2 ratios of −1 and +1. Data points to the left of center represent losses and those to the right of center represent gains.
- Figure S2. Distribution of high-level amplicons on chromosome 18 in 106 diagnostic FL cohort (JPG, 18.4 KB)
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A high-level amplicon in 18q12.2 recurrent in seven of 106 (6.6%) cases was identified by a computational thresholding method that defined amplicons as 1) one that consisted of 3 or more contiguous BAC’s, 2) the log ratio of a BAC in an amplicon was at least 4 standard deviations above the mean log ratio of the sample, and 3) the frequency with which an amplicon occurred was at least 5%. Other amplicons that did not meet the 5% cutoff were also shown here. X-axis represents the BAC clones on chromosome 18. Y-axis represents the 106 diagnostic FL cases in this study.
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