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Blood, Vol. 112, Issue 10, 4328-4336, November 15, 2008 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef Protection from graft-versus-host disease with a novel B7 binding site–specific mouse anti–mouse CD28 monoclonal antibody Blood Beyersdorf et al. 112: 4328 Supplemental materials for: Beyersdorf et al Files in this Data Supplement: Figure S1. E18 co-stimulates T cells in vitro (JPG, 32.2 KB) - Time kinetics of 3H-thymidine incorporation into BALB/c spleen cells stimulated with 0.25 µg/1 × 106 cells anti-CD3 mAb in the absence or presence of 1 µg/ 1 × 106 cells E18, 37.51 or E18 Fab. 3H-thymidine was added 16 hours before the end of the culturing period. Figure S2. Activation of CD4+ Vβ8+ cells after SEB injection in vivo (JPG, 51.2 KB) - BALB/c mice were injected with E18, E18 Fab or control mAb as indicated followed by SEB stimulation. One day (left graph, experiment I) or three days (right graph, experiment II) after SEB application the frequencies of CD69+ among CD4+ Vβ8+ cells were determined by flow cytometry. Bars indicate means ± SD of three animals per group. Figure S3. Induction of apoptosis in allogeneic CD4+ T cells by E18 in vivo (JPG, 49.7 KB) - The percentages of AnnexinV+ cells were determined among CD4+ CD90.1+ Foxp3− donor T cells on day six after transplantation into BALB/c recipient mice that had been treated as indicated. Horizontal bars represent the medians per group. Data from two separate experiments were pooled. This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

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