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Blood, Vol. 112, Issue 13, 5103-5110, December 15, 2008
Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor–CD3 expression in enteropathy-associated T-cell lymphoma
Blood Tjon et al.
112: 5103
Supplemental materials for: Tjon et al
Files in this Data Supplement:
- Figure S1. Retroviral introduction of exogenous TCRα-chains does not restore surface TCRαβ expression on cell line P1 (JPG, 84.8 KB)
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FACS analysis after retroviral transduction of cells from RCD cell line P1 and a Jurkat TCRα-negative clone with TCRAV14, TCRAV18 and TCRAV30. GFP expression (successful TCRα introduction) is plotted against surface TCRαβ expression. The upper panel shows nontransduced (NT) P1 cells and P1 cells transduced with TCRAV14, TCRAV18 and TCRAV30. The lower panel shows nontransduced (NT) TCRα-negative Jurkat cells and TCRα-negative Jurkat cells transduced with TCRAV14, TCRAV18 and TCRAV30. Percentages of double positive cells are indicated.
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