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Blood, Vol. 112, Issue 12, 4507-4511, December 1, 2008
Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations
Blood Tunstall-Pedoe et al.
112: 4507
Supplemental materials for: Tunstall-Pedoe et al
Files in this Data Supplement:
- Document 1. Supplemental materials and methods (PDF, 22.3 KB)
- Figure S1. Peripheral blood from DS and normal fetuses (JPG, 73.5 KB)
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(A) Representative blood films from a normal fetus at 16 weeks gestation and (B) a DS fetus at 17 weeks gestation (40× objective) with high power view of giant platelet (detail; 100×). Giant platelets, many with bizarre morphology, were seen on all fetal blood smears and represented 11–15% of platelets seen on the smear. (C) Platelet counts of peripheral blood were available from 10 normal fetuses and 4 with DS (all DS neonates were screened for exon 2/3 GATA1 mutations, as described in Document 1, and no mutations were detected).
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