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Blood, Vol. 113, Issue 21, 5217-5227, May 21, 2009 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner Blood Cui et al. 113: 5217 Supplemental materials for: Cui et al Files in this Data Supplement: Figure S1. LY294002 inhibits phosphorylation and hence activity of Akt as does SP600125 for JNK (JPG, 48.7 KB) - Figure S2. Alternative inhibitors of JNK and MDM2 stabilise p53 (JPG, 48 KB) - The alternative MDM2 antagonist NSC66811 like nutlin-3 results in stabilisation of p53 as determined 24 hours following treatment as indicated. Likewise, an alternative JNK inhibitor (JNK inhibitor I) has similar effects to SP600125 in the stabilisation of p53. Figure S3. p53 localises to filamentous-like cytoskeletal structures in the cytoplasm in a PI 3-Kinase dependent manner (JPG, 58.7 KB) - Confocal imaging for p53 demonstrates attachment of p53 to filamentous-like structures in the cytoplasm. The staining becomes more diffuse following treatment of cells with the PI 3-Kinase inhibitor LY294002. This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

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