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Blood, Vol. 113, Issue 13, 3027-3030, March 26, 2009

FAS-L, IL-10, and double-negative CD4–CD8– TCR /β+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function
Blood Magerus-Chatinet et al.
113: 3027
Supplemental materials for: Magerus-Chatinet et al
Files in this Data Supplement:
- Figure S1. FAS-mediated apoptosis in ALPS patients (JPG, 42.3 KB)
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(A) Results for FAS-induced apoptosis in vitro on activated T cells from ALPS patients with FAS mutations, healthy age-matched controls (HCs) and relatives carrying (MPRs) or not (HR) a FAS mutation. (B) Comparison of the FAS-induced apoptosis obtained in parallel for the patients and their relatives carrying the same FAS mutation. Values are expressed as the percentages of PHA-activated T-cell blasts that underwent apoptosis in vitro. The wide horizontal bars denote the mean values for each group. P values for inter-group differences in the Mann-Whitney test are shown above the data.

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