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Blood, Vol. 113, Issue 17, 3896-3902, April 23, 2009
CNS events in elderly patients with aggressive lymphoma treated with modern chemotherapy (CHOP-14) with or without rituximab: an analysis of patients treated in the RICOVER-60 trial of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL)
Blood Boehme et al.
113: 3896
Supplemental materials for: Boehme et al
RICOVER-60 trial members The RICOVER-60 study was supported by Deutsche Krebshilfe. Roche provided rituximab during the first year of recruitment. Report writing: Michael Pfreundschuh, Markus Loeffler, Marita Ziepert Data management: B Mann, U Schönwiese, L Martin Montanez, C Schorpp, T Rixecker Database: M Kunert, B Wicklein Biometry: ML, MZ, S Zeynalova. Clinical consultants: FH, RS, JS, VP. The following investigators and institutions recruited patients for this study:
Saarland University Medical School, Homburg, Germany—MP
University Hospital, Magdeburg, Germany—MM
Mannheim Hospital, Mannheim, Germany—EL
University Hospital, Köln, Germany—MR
Großhadern der LMU Hospital, München, Germany—CN
Hospital Maternity House of Borromäerinnen, Trier, Germany—MC
Carl-Thiem Hospital, Cottbus, Germany—NP
University Hospital Eppendorf, Hamburg, Germany—M deWit
St Josefs and St Marien Hospital, Hagen, Germany—HE
Medical Hospital, Ruprecht-Karls University, Heidelberg Germany—AH
Stadt Ludwigshafen Hospital, Ludwigshafen, Germany—MH
University Hospital, Freiburg, Germany—RM
AK St Georg, Hamburg, Germany—NS
Georg August University, Göttingen, Germany—LT
Evangelisches Krankenhaus, Germany—LB
University Hospital, Münster, Germany—RL
Städtische Hospital, Oldenburg, Germany—BM
Evangelisches Diakonie-Krankenhaus, Bremen, Germany—K H Pflüger
University Hospital, Essen, Germany—U Dührsen
Städtisches Krankenhaus Martha-Maria, Halle/Saale, Germany—W Schütte
St Bernward Krankenhaus, Hildesheim, Germany—U Kaiser
Städtisches Hospital, Karlsruhe, Germany—M Bentz
Katharinen Hospital, Stuttgart, Germany— H G Mergenthaler
University Hospital, Ulm, Germany—S Wessendorf
University Hospital Clinic, Bonn, Germany—T Sauerbruch
St Antonius Hospital, Eschweiler, Germany—R Fuchs
Klinikum rechts der Isar, München, Germany—C Peschel
Dr Horst-Schmidt Hospital, Wiesbaden, Germany—N Frickhofen
University Hospital Charité, Berlin, Germany—G Dölken
University Hospital Benjamin Franklin, Berlin, Germany—E Thiel
University Hospital, Rostock, Germany— M Freund
Helios Hospital, Wupperta, Germany—A Raghavachar
Städtisches Klinikum St Georg, Leipzig, Germany— L Mantovani-Löffler
Krankenhaus Maria-Hilf II Franziskushaus, Mönchengladbach, Germany—U Graeven
Rostock Südstadt Hospital, Rostock, Germany— B Krammer-Steiner
St Marien Hospital, Amberg, Germany—L Fischer von Weikersthal
Zentralklinikum, Augsburg, Germany— G Schlimok
Krankenhaus Nordwest Frankfurt, Frankfurt/Main, Germany—E Jäger
Joint medical practice: Aldaoud/Schwarzer, Leipzig, Germany— A Aldaoud
Sana Kliniken Lübeck GmbH, Krankenhaus Süd, Lübeck, Germany—S Fetscher
St Antonius Hospital, Wuppertal, Germany— M Sandmann
Rigshospitalet, DK-Kopenhagen, Germany—M Hansen
Städtische Krankenanstalten, Krefeld, Germany—T Frieling
University Hospital Schleswig-Holstein, Lübeck, Germany—T Wagner
St Vincentius Hospitals, Karlsruhe, Germany— J Mezger
Altstadt Hospital, Magdeburg, Germany—E Kettner
Oncological Priority Practice, Münster, Germany—C Lerchenmüller
St Marienkrankenhaus, Siegen, Germany—T Gaska
Kreiskrankenaus, Aurich, Germany— W Langer
Märkische Hospital, Lüdenscheid, Germany—G Heil
University Hospital Regensburg, Regensburg, Germany—R Andreesen
Allgemeines Krankenhaus, Celle, Germany—S Hollerbach
Ernst von Bergdamm Hospital, Potsdam, Germany—G Maschmeyer
Kantonsspital, CH-St Gallen, Germany—T Cerny
Municipal Hospital, Braunschweig, Germany—B Wörmann
Franz Hospital, Dülmen, Germany—G Dresemann
Johann-Wolfgang-GoetheUniversity Hospital, Frankfurt/Main, Germany—L Bergmann
Municipal Hospital, Fulda, Germany—H G Höff kes
Ernst-Moritz-Arndt University, Greifswald, Germany—G Dölken
Amtssygehuset i Herlev, DK-Herlev, Germany—H Johnsen
St Vincenz-Krankenhaus, Limburg, Germany— KP Schalk
Bürgerhospital, Stuttgart, Germany—HG Mergenthaler
Krankenhaus der Barmherzigen Brüder, Trier, Germany—C B Kölbel
Kantonsspital, CH-Baden, Germany—J H Beer
Ceske Budesovice Hospital, CZ-Budesovice, Germany—J Fischer
Allgemeines Krankenhaus, Hagen, Germany—T Scholten
St Elisabeth and St Barbara Krankenhaus, Halle/Saale, Germany—R Willenbrock
St Marienhospital, Hamm, Germany— H Dürk
Medizinische Hochschule, Hannover, Germany—A Ganser
Municipal Hospital, Hildesheim, Germany—F Schmitz
KMT-Klinik, Idar-Oberstein, Germany—A A Fauser
Evang Stift St Martin, Koblenz, Germany— HH Dormeyer
Municipal Hospital, Nettetal, Germany—M Pauw
Joint medical practice: Otremba/Reschke/Hinrichs, Oldenburg, Germany— B Otremba
Diakonie Hospital, Stuttgart, Germany—R Mück
Kreiskrankenhaus, Waldbröl, Germany—S Brettner
Joint medical practice: Hahn/Müller, Ansbac, Germany—M Hahn
Kreiskrankenhaus am Plattenwald, Bad Friedrichshall, Germany—D Bürkle
Ermstalklinik, Bad Urach, Germany—M Schmelz
Oncology Institute of Svizzera Italiana, CH-Bellizona, Italy—E Zucca
Practice for Haematology and Oncology, Freiburg, Germany—T Reiber
Practice for Haematology and Oncology, Freiburg, Germany—D Semsek
University Hospital Halle-Wittenberg, Halle/Saale, Germany—H J Schmoll
Medical practice: Hahnfeld, Jena, Germany—S Hahnfeld
Landshut Hospital, Landshut, Germany—B Kempf
University Hospital, Motol, Prague, Czech Republic—J Prausova
University Hospital, Würzburg, Germany— H Einsele
DRK Kliniken Berlin Köpenick, Berlin, Germany— C Rudolph
Vivantes Neukölln Hospital, Berlin, Germany—C Mayr
Zentralkrankenhaus Reinkenheide, Bremerhaven, Germany—W Kurtz
Oncology Priority Practice, Celle, Germany—F Marquard
Municipal Hospital, Esslingen, Germany—M Geissler
St Josef Hospital, Gelsenkirchen, Germany—G Meckenstock
Kreis Herford Hospital, Herford, Germany—U Schmitz-Huebner
Westpfalz-Klinikum, Kaiserslautern, Germany—H Link
Joint medical practice: Siehl/Söling, Kassel, Germany—U Söling
Municipal Hospital, Kiel, Germany— M Kneba
Joint medical practice: Schmitz/Steinmetz/Gabor, Köln, Germany—S Schmitz
Joint medical practice: Stauch/Uhle, Kronach, Germany—M Stauch
Caritas-Krankenhaus, Lebach, Germany— S Kremers
Onkologische Schwerpunktpraxis, Leer – L Müller
Klinikum Lippe-Lemgo GmbH, Lemgo—F Hartmann
Dreifaltigkeitshospital, Lippstadt—L Heidenreich
Joint medical practice: Schröder/Sieg, Mülheim/Ruhr—J Schröder
Städtisches Krankenhaus München- Harlaching, München – L Lutz
Oncology Priority Practice, Neumarkt, Germany—E Ladda
Kreiskrankenhaus, Neumarkt, Germany— F Tympner
Oncology Priority Practice, Neunkirchen, Germany— P Schmidt
Joint medical practice: Balló/Böck, Off enbach/Mai, Germany—P Böck
General University Hospital, Prague Czech Republic—P Klener
Martin-Luther-Krankenhaus, Schleswig, Germany—M Schoettler
Helios Hospital, Schwelm, Germany— U Müschenborn
Joint medical practice: Demandt/Ernstberger, Straubing, Germany—M Demandt
Joint medical practice: Rendenbach/Laubenstein, Trier, Germany—B Rendenbach
Joint medical practice: Forstbauer/Ziske, Troisdorf, Germany—H Forstbauer
St Marienhospital, Vechta, Germany—J Diers
Triemli City Hospital, Zürich, Switzerland—H Honegger
Joint medical practice: Weinberg/Tummes/Guggenberger, Aachen, Germany—D Tummes
Kantonsspital, CH-Aarau, Germany—W Mingrone
Kreiskrankenhaus Bad Säckingen, Bad Säckingen, Germany—G Lunke
Institute for Medical Oncology, Inselspital, Bern, Switzerland—M F Fey
Krankenhaus Bietigheim, Bietigheim, Germany—G Dietrich
Knappschaftskrankenhaus, Bottrop, Germany—G Trenn
Practice for Haematology and Oncology, Burgwedel, Germany—G Obst
Municipal Hospital, Darmstadt, Germany—D Fritze
Hans-Susemihl-Krankenhaus, Emden, Germany— H Becker
GMP Tesch/Grunewald/Klippstein/Knauf, Frankfurt/Main, Germany—H Tesch
Krankenhaus Gummersbach, Gummersbach, Germany—M Sieber
St Salvator-Krankenhaus, Halberstadt, Germany— W Kraus
Marienhospital, Herne, Germany—D Strumberg
Klinikum Kempten-Oberallgäu, Kempten, Germany—O Prümmer
Practice for Haematology and Oncology, Krefeld, Germany—M Neise
Onkologische Praxis am Diakonissenhaus, Leipzig, Germany—B Peuser
University Hospital, Mainz, Germany—C Huber
Practice for Internal Medicine, Naunhof, Germany—J Uhlig
Practice for Haematology and Oncology, Norderstedt, Germany—R Hoff mann
Marienhospital, Osnabrück, Germany— M Müller
Practice for Haematology and Oncology, Regensburg, Germany—R Dengler
Leopoldina-Krankenhaus, Schweinfurt, Germany—S Kanzler
Joint medical practice: Springer/Fiechtner, Stuttgart, Germany—G Springer
Spital Uster, Uster, Switzerland—G Tscherry
University Hospital, Zürich, Switzerland— A Knuth
Heinrich-Braun-Krankenhaus/Städt. Klinikum, Zwickau, Germany—U Kreibich
Joint medical practice: Brudler/Heinrich/Bangerter, Augsburg, Germany—B Heinrich
Kreiskrankenhaus Bad Hersfeld, Bad Hersfeld, Germany—R Nowak
Helios-Klinikum Bad Saarow/Fürstenwalde, Bad Saarow, Germany—U Wruck
Joint medical practice: Weinert/Bettinger, Bad Salzufl en, Germany—R Weinert
Joint medical practice: Ihle/Blau, Berlin, Germany—I Blau
Joint medical practice: Herrenberger/Keitel-Wittig/Kirsch, Berlin, Germany— J Herrenberger
Evangelisches Waldkrankenhaus Spandau, Berlin, Germany—E Aulbert
Campus Charité Mitte, Berlin, Germany— K Possinger
University Hospital, Bochum, Germany—W Schmiegel
Medizinische Universitätsklinik u Poliklink I, Bonn, Germany— I Schmidt-Wolf
Johanniter Krankenhaus, Bonn, Germany—Y Ko
Onkologische Schwerpunktpraxis, Borken, Germany—R Kellner
HOK, Fakultní nemocnice Brno, Brno-Bohunice, Czech Republic—I Vášová
Practice for Haematology and Oncology, Coesfeld, Germany—M Glados
St Johannes Hospital, Dortmund, Germany—H J Pielken
St Marienkrankenhaus, Frankfurt/Main, Germany—F Hartmann
Evangelisches Diakoniekrankenhaus, Freiburg, Germany—H P Allgaier
Klinikum Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany—H Lambertz
Joint medical practice: Mittermüller/Göldel, Germering—J Mittermüller
Wilhelm-Anton-Hospital, Goch—V Runde
Joint medical practice: Kollbach/Thomas, Grefrath, Germany— R Thoms
Allgemeines Krankenhaus/Strahlenklinik, Hagen, Germany—R Souchon
Joint medical practice: Rohrberg/Hurtz/Schmidt/Frank-Gleich, Halle/Saale, Germany—M Schmidt
A K Altona, Hamburg, Germany—D Braumann
Marienkrankenhaus, Hamburg, Germany—U Vanhoefer
Klinikum Region Hannover, Germany—Krankenhaus Siloah, Hannover, Germany—H Kirchner
Municipal Hospital, Herrsching, Germany—H Dietzfelbinger
Evangelisches Krankenhaus, Holzminden, Germany—C Manegold
Klinikum Hoyerswerda, Hoyerswerda, Germany—K Gasiorek
Rotes Kreuz Krankenhaus, Kassel, Germany—C Löser
Krankenhaus Holweide, Köln, Germany—I Meuthen
Kliniken der Stadt Köln, Krankenhaus Merheim, Köln-Merheim, Germany—E Stoelben
Park-Krankenhaus Leipzig- Südost, Leipzig, Germany—U Halm
Kreiskrankenhaus, Lörrach, Germany—HH Osterhues
Kath Klinikum/St Vincenz- und Elisabeth- Hospital, Mainz, Germany—W Dippold
University Hospital, Marburg, Germany—A Neubauer
Städtisches Krankenhaus München-Schwabing, München, Germany—C Nerl
Joint medical practice: Abenhardt/Bojko/Bosse/Riedner, München, Germany—D Bosse
Klinikum der Universität München Innenstadt, München, Germany—F Oduncu
Städtisches Klinikum Neunkirchen, Neunkirchen, Germany—A Bierbrauer zu Brennstein
DRK-Krankenhaus Neuwied, Neuwied, Germany— W Gickler
Joint medical practice: Detken/Seraphin, Northeim, Germany—S Detken
Klinikum Nürnberg, Nürnberg, Germany— M Wilhelm
Schloßbergklinik, Oberstaufen, Germany—K Zellmann
Paracelsus-Klinik, Osnabrück, Germany—S Frühauf
Asklepios Klinik Parchim, Parchim, Germany—W Schreiber
Krankenhaus Siloah, Pforzheim, Germany—P Weber
Fakultni Nemocnice, Prague, Czech Republic—T Kozek
stav hematologie a krevní transfuse, Prague, Czech Republic—N Mesta, P Klemer
Sana-Klinikum Remscheid GmbH, Remscheid, Germany—A Wehmeier
Praxis für Hämatologie und Onkologie, Rostock, Germany—V Lakner
Joint medical practice: Würmell/Baldus/Giesder-Würmell, Rüsselsheim, Germany—M Baldus
Joint medical practice: Jacobs/Daus/Schmits, Saarbrücken, Germany— G Jacobs
Klinikum Schwerin, Schwerin, Germany—D Hähling
St-Lukas-Klinik, Solingen, Germany—KH Beckers
Krankenhaus Maria-Hilf, Stadtlohn, Germany—C Deutike
Onkologische Schwerpunktpraxis, Trier, Germany—M Grundheber
Masarykova Nemocnice, Usti nad Labem, Czech Republic—M Lysy
Vejle Sygehus, DK-Vejle, O Gadeberg
Klinikum der Stadt, Villingen-Schwenningen, Germany—W Brugger
Asklepios Nordseeklinik, Westerland, Germany—W Nettekoven.
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