|
|
Blood, Vol. 114, Issue 9, 1859-1863, August 27, 2009
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
Blood Loh et al.
114: 1859
Supplemental materials for: Loh et al
Files in this Data Supplement:
- Table S1. CBL primers used for Exons 8 and 9 (PDF, 43.6 KB)
- Table S2. CBL mutations detected in CMML patients (PDF, 13.8 KB)
- Figure S1. SNP 6.0 arrays are depicted for 27 patients with JMML, some of whom have paired samples (noted with the same HM number and with a “b” (buccal), “c” (cord blood), or “e” suffix (EBV) lines (JPG, 60.1 KB)
-
These patients represent a wide variety of JMML patients, some of whom have syndromes or other clinical or genetic features. Patients 27J, 44J, HM1658, HM1854, HM1993, and J246, all demonstrated homozygous lesions in CBL. Interestingly, J246 did not exhibit 11q UPD. Of note, the diagnostic specimen from HM 1854 demonstrated 11q acquired UPD compared to the cord blood sample, HM1854c, which did not.
|
|
