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Blood, Vol. 113, Issue 26, 6619-6628, June 25, 2009
KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells
Blood Henson et al.
113: 6619
Supplemental materials for: Henson et al
Files in this Data Supplement:
- Figure S1. No increase in telomerase expression or IL-2 production following KLRG1 blockade (JPG, 77.2 KB)
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(A) Representative examples of KLRG1 staining in young and old individuals on whole CD8+ T cells. (B) Representative examples of KLRG1 staining on CD8+ CD28/CD27 T cells subsets in young and old individuals. (C) Data showing telomerase activity after 3 days following E-cadherin blockade in CD8+ CD28/27 T-cell subsets determined using the TeloTAGGG telomerase ELISA kit from Roche. Graph shows the mean ± SE for 3 donors. (D) Graph showing IL-2 production in CD8+ T cells following KLRG1 blockade. Stimulation index was calculated by determining the ratio between the percentage of CD8+ cells producing cytokine in the presence of anti-CD3 stimulation versus E-cadherin blockade.
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