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Blood, Vol. 114, Issue 1, 64-73, July 2, 2009
Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells
Blood Matsushima et al.
114: 64
Supplemental materials for: Matsushima et al
Files in this Data Supplement:
- Table S1. Liver function in mice after CRA treatment (PDF, 388 KB) -
BALB/c mice received four repeated i.p. injections with CRA or DMSO alone. Serum samples were examined for the indicated parameters. Data represent the mean ± SD (n = 5). P values by student’s t-test compared with the no-treatment group are shown in the parentheses. IU, international units; AST, aspartate aminotransferase; ALT, alanine aminotransferase; T-Bil, total bilirubin; ALP, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; BUN, blood urea nitrogen.
- Figure S1. In vitro impact of CRA on CCR7 expression by BM-DCs (JPG, 31.3 KB)
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BM-DCs were cultured with CRA or PBS in the presence or absence of LPS for 24 h and then examined for CCR7 expression. (A) The data shown are CCR7 expression profiles (filled histograms) and control staining profiles with isotype-matched control IgG (open histograms). (B) The data shown are the means ± SD (n = 3) of the mean fluorescence intensity for CCR7 and the % cell viability measured by PI uptake. Asterisks indicate statistically significant (*P < 0.05) differences.
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