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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dhodapkar, M. V. Articles by Steinman, R. M. Search for Related Content PubMed PubMed Citation Articles by Dhodapkar, M. V. Articles by Steinman, R. M. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 July 2002, Vol. 100, No. 1, pp. 174-177 IMMUNOBIOLOGY Antigen-bearing immature dendritic cells induce peptide-specific CD8+ regulatory T cells in vivo in humans Madhav V. Dhodapkar and Ralph M. Steinman From the Laboratory of Tumor Immunology and Immunotherapy and the Laboratory of Cellular Physiology and Immunology, Rockefeller University; New York, NY; and the Hematology Division, Memorial Sloan-Kettering Cancer Center, New York, NY. Regulatory T cells (TRs) can suppress the function of other effector T cells in the setting of autoimmunity, transplantation, and resistance to tumors. The mechanism for the induction of TRs has not been defined. We previously reported that an injection of immature dendritic cells (DCs) pulsed with influenza matrix peptide (MP) led 7 days later to antigen-specific silencing of effector T-cell function in the blood of 2 healthy human subjects. Here, we found that interferon--producing effectors return by 6 months. Importantly, in mixing experiments, CD8+ T cells from the sample obtained 7 days after injection could suppress MP-specific effectors obtained before injection and those in recovery samples. This suppression or regulation was specific for the immunizing peptide (MP) and cell-dose dependent, and it required contact between the 2 samples. These data show the capacity of immature DCs to induce antigen-specific regulatory CD8+ T cells in humans. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. McGill, J. W. Heusel, and K. L. Legge Innate immune control and regulation of influenza virus infections J. Leukoc. Biol., October 1, 2009; 86(4): 803 - 812. [Abstract] [Full Text] [PDF] C. Luther, E. Adamopoulou, C. Stoeckle, V. Brucklacher-Waldert, D. Rosenkranz, L. Stoltze, S. Lauer, S. Poeschel, A. Melms, and E. Tolosa Prednisolone Treatment Induces Tolerogenic Dendritic Cells and a Regulatory Milieu in Myasthenia Gravis Patients J. Immunol., July 15, 2009; 183(2): 841 - 848. [Abstract] [Full Text] [PDF] T. Osada, C. Y. Woo, M. McKinney, X. Y. 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