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Prepublished online as a Blood First Edition Paper on July 12, 2002; DOI 10.1182/blood-2002-02-0523.
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Blood, 15 November 2002, Vol. 100, No. 10, pp. 3822-3824
BRIEF REPORT
Initial characterization of TREM-like transcript (TLT)-1: a
putative inhibitory receptor within the TREM cluster
A. Valance Washington,
Laura Quigley, and
Daniel W. McVicar
From the Laboratory of Experimental Immunology,
National Cancer Institute-Frederick, MD.
The TREMs (triggering receptors expressed on myeloid cells)
represent a family of 5 receptors clustered on murine chromosome 17. TREMs 1 and 2 affect various aspects of myeloid cell activation and
development, including responsiveness to lipopolysaccharide and
regulation of dendritic cell maturation, yet no inhibitory receptor has
been demonstrated within this cluster. Here we characterize TLT-1
(TREM-like transcript-1), a putative inhibitory receptor within the
TREM cluster that contains an extracellular V-set Ig domain, a
proline-rich region, and an immune receptor tyrosine-based inhibitory
motif (ITIM) in its cytoplasmic tail. To our knowledge, TLT-1 is the
first ITIM-containing receptor carrying a potential Src homology 3 domain ligand. TLT-1 transcripts are abundant in bone marrow cells, but
not in lymphocytes, and phosphorylated TLT-1 associates with SHP-1,
suggesting that it is indeed an inhibitory receptor. Based on these
characteristics, it is likely that TLT-1 regulates the signaling of the
TREM family receptors.
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