Blood, 1 December 2002, Vol. 100, No. 12, pp. 4139-4145
NEOPLASIA
Hodgkin and Reed-Sternberg cell-associated autoantigen
CLIP-170/restin is a marker for dendritic cells and is involved in the
trafficking of macropinosomes to the cytoskeleton, supporting a
function-based concept of Hodgkin and Reed-Sternberg
cells
Ugur Sahin,
Frank Neumann,
Özlem Türeci,
Rudolf Schmits,
Franck Perez, and
Michael Pfreundschuh
From Medizinische Klinik I, Saarland University Medical
School, Homburg, Germany; and Institute Curie, Paris,
France.
Little is known about the distribution in normal cells of CLIP-170,
a linkage mediator between endocytic vesicles and microtubules, and
restin, a splice variant encoded by the same gene and marker for
Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin disease. Although
only trace amounts of CLIP-170/restin are present in peripheral blood
mononuclear cell subpopulations, monocyte-derived dendritic cells (DCs)
and interleukin-4 (IL-4) + CD40L-activated B cells express high
levels of CLIP-170/restin. CLIP-170/restin colocalizes preferentially
with membranes of intermediate macropinocytic vesicles, suggesting a
new function of CLIP-170/restin in the trafficking of macropinosomes to
the cytoskeleton, which is a crucial step in antigen presentation. The
strong expression of CLIP-170/restin in HRS cells, DCs, and activated B
cells underscores their functional similarities supporting a
function-based concept of HRS cells as professional antigen-presenting cells.
