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Blood, 15 July 2002, Vol. 100, No. 2, pp. 383-390
PLENARY PAPER
Characterization of a new subpopulation of mouse
CD8 + B220+ dendritic cells endowed with type
1 interferon production capacity and tolerogenic potential
Pilar Martín,
Gloria Martínez del Hoyo,
Fabienne Anjuère,
Cristina Fernández Arias,
Héctor Hernández Vargas,
Africa Fernández-L,
Verónica Parrillas, and
Carlos Ardavín
From the Department of Cell Biology, Faculty of
Biology, Complutense University, Madrid, Spain; and Faculté de
Médecine Pasteur, INSERM U364, Nice, France.
We describe a new B220+ subpopulation of immaturelike
dendritic cells (B220+ DCs) with low levels of expression
of major histocompatibility complex (MHC) and costimulatory molecules
and markedly reduced T-cell stimulatory potential, located in the
thymus, bone marrow, spleen, and lymph nodes. B220+ DCs
display ultrastructural characteristics resembling those of human
plasmacytoid cells and accordingly produce interferon- after virus
stimulation. B220+ DCs acquired a strong antigen-presenting
cell capacity on incubation with CpG oligodeoxynucleotides, concomitant
with a remarkable up-regulation of MHC and costimulatory molecules and
the production of interleukin-12 (IL-12) and IL-10. Importantly, our
data suggest that nonstimulated B220+ DCs represent a
subset of physiological tolerogenic DCs endowed with the capacity to
induce a nonanergic state of T-cell unresponsiveness, involving the
differentiation of T regulatory cells capable of suppressing
antigen-specific T-cell proliferation. In conclusion, our data support
the hypothesis that B220+ DCs represent a lymphoid organ
subset of immature DCs with a dual role in the immune system exerting
a tolerogenic function in steady state but differentiating on microbial
stimulation into potent antigen-presenting cells with type 1 interferon
production capacity.
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