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Blood, 15 July 2002, Vol. 100, No. 2, pp. 721-723
BRIEF REPORT
Analysis of the hematopoietic potential of muscle-derived cells
in mice
Hartmut Geiger,
Jarrod M. True,
Barry Grimes,
Elizabeth J. Carroll,
Roger A. Fleischman, and
Gary Van
Zant
From the Departments of Internal Medicine and
Physiology, University of Kentucky Medical Center; and the Veterans
Administration Hospital, Lexington, KY.
Cells in murine muscle have been reported to differentiate into
hematopoietic stem and progenitor cells and thus repopulate the
hematopoietic system of an irradiated animal. This activity was
attributed to muscle stem cells. We used an in vitro and in vivo
approach to identify the hematopoietic repopulating activity found in
muscle tissue of mice by antibody staining and cell sorting. We
confirmed existence of a hematopoietic repopulating cell in muscle tissue, but the data strongly suggest that repopulation is due
not to muscle stem cells but to hematopoietic cells present in muscle
tissue. Unexpectedly, the blood-forming cells were enriched in muscle
relative to their frequency in peripheral blood.
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