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Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 September 2002, Vol. 100, No. 6, pp. 2153-2158 IMMUNOBIOLOGY Human fetuses are able to mount an adultlike CD8 T-cell response Emmanuel Hermann, Carine Truyens, Cristina Alonso-Vega, Jos Even, Patricia Rodriguez, Aurélie Berthe, Eric Gonzalez-Merino, Faustino Torrico, and Yves Carlier From the Laboratoire de Parasitologie, Faculté de Médecine and the Département de Génétique Médicale, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium; CUMETROP/LABIMED, Faculdad de Medecina, Universidad Mayor de San Simon, Cochabamba, Bolivia; and Institut National de la Santé et de la Recherche Médicale U277, Département d'Immunologie, Institut Pasteur, Paris, France. Fetal/neonatal immune responses generally are considered to be immature and weaker than that of adults. We have studied the cord-blood T cells of newborns congenitally infected with Trypanosoma cruzi, the protozoan agent of Chagas disease. Our data demonstrate a predominant activation of CD8 T cells expressing activation markers and armed to mediate effector functions. The analysis of the T-cell receptor beta chain variable repertoire shows the oligoclonal expansion of these T lymphocytes, indicating that activation was driven by parasite antigens. Indeed, we have detected parasite-specific CD8 T cells secreting interferon- after coincubation with live T cruzi. This response is enhanced in the presence of recombinant interleukin-15, which limits the T-cell spontaneous apoptosis. These findings point out that the fetal immune system is more competent than previously appreciated, since fetuses exposed to live pathogens are able to develop an adultlike immune CD8 T-cell response. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. N. Diez, S. Manattini, J. C. Zanuttini, O. Bottasso, and I. Marcipar The Value of Molecular Studies for the Diagnosis of Congenital Chagas Disease in Northeastern Argentina Am J Trop Med Hyg, April 1, 2008; 78(4): 624 - 627. [Abstract] [Full Text] [PDF] I. Malhotra, A. N. Wamachi, P. L. Mungai, E. Mzungu, D. Koech, E. Muchiri, A. M. Moormann, and C. L. King Fine Specificity of Neonatal Lymphocytes to an Abundant Malaria Blood-Stage Antigen: Epitope Mapping of Plasmodium falciparum MSP133 J. Immunol., March 1, 2008; 180(5): 3383 - 3390. [Abstract] [Full Text] [PDF] M. Virreira, C. Truyens, C. Alonso-Vega, L. 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