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Prepublished online as a Blood First Edition Paper on May 13, 2002; DOI 10.1182/blood-2002-01-0073. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-01-0073v1 100/8/2926    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sakai, I. Articles by Fujita, S. Search for Related Content PubMed PubMed Citation Articles by Sakai, I. Articles by Fujita, S. Related Collections Neoplasia Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 October 2002, Vol. 100, No. 8, pp. 2926-2931 NEOPLASIA Constitutive expression of SOCS3 confers resistance to IFN- in chronic myelogenous leukemia cells Ikuya Sakai, Kazuto Takeuchi, Hayato Yamauchi, Hirosi Narumi, and Shigeru Fujita From the First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan. Because suppressor of cytokine signaling (SOCS) proteins are negative regulators of cytokine-induced signaling, it has been hypothesized that aberrant SOCS expression confers resistance against cytokine therapy. This study reports on the constitutive expression of SOCS3 in most chronic myelogenous leukemia (CML) cell lines, which are resistant to treatment with interferon  (IFN-). In contrast, the KT-1/A3 cell line, in which constitutive expression of SOCS3 is barely detectable, is sensitive to IFN- treatment. Forced expression of SOCS3 in the KT-1/A3 cell line confers resistance to IFN- treatment. Furthermore, most of the blast cells from patients in CML blast crisis, which are usually resistant to IFN- therapy, showed constitutive expression of SOCS3. These findings indicate that constitutive SOCS3 expression affects the IFN- sensitivity of CML cell lines and blast cells from patients with CML blast crisis. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Katsoulidis, A. Sassano, B. Majchrzak-Kita, N. Carayol, P. Yoon, A. Jordan, B. J. Druker, E. N. Fish, and L. C. Platanias Suppression of Interferon (IFN)-inducible Genes and IFN-mediated Functional Responses in BCR-ABL-expressing Cells J. Biol. 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