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Prepublished online as a Blood First Edition Paper on July 5, 2002; DOI 10.1182/blood-2002-02-0638.
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Blood, 1 November 2002, Vol. 100, No. 9, pp. 3295-3303
IMMUNOBIOLOGY
Subtractive hybridization reveals the expression of
immunoglobulinlike transcript 7, Eph-B1, granzyme B, and 3 novel
transcripts in human plasmacytoid dendritic cells
Marie-Clotilde Rissoan,
Thomas Duhen,
Jean-Michel Bridon,
Nathalie Bendriss-Vermare,
Catherine Péronne,
Blandine de
Saint Vis,
Francine Brière, and
Elizabeth E. M. Bates
From the Laboratory for Immunological Research,
Schering-Plough, Dardilly, France.
Recent studies in humans have highlighted the importance of a
distinct cellular entity, the plasmacytoid dendritic cell (PDC). To
identify genes for which expression is restricted to human PDCs, a cDNA
subtraction technique was applied using cDNA from activated
monocyte-derived DCs (MDDCs) as competitor. In the 650 sequences
analyzed, 25% were for B-cell transcripts. We also found lymphoid-related genes, immunoglobulinlike transcript 7 (ILT7), granzyme B (GrB), Spi-B, and the receptor tyrosine kinase Eph-B1. Granzyme B was up-regulated on activation, and protein was detected only in PDCs. Eph-B1 protein was expressed in the cytoplasm and the
nuclei of PDCs and MDDCs, respectively. Interestingly, several novel
molecules have been identified that were predicted to encode for a type
2 transmembrane protein (BRI3), a putative cytokine (C-15,
a cysteine-rich-secreted protein), and a type 1 leucine-rich repeat
protein (MAPA). The identification of genes expressed in PDCs provides
new insights into their function and origin.
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