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Prepublished online as a Blood First Edition Paper on August 15, 2002; DOI 10.1182/blood-2002-06-1823. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-06-1823v1 101/1/101    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zakaria, N. Articles by Devlin, J. Search for Related Content PubMed PubMed Citation Articles by Zakaria, N. Articles by Devlin, J. Related Collections Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 January 2003, Vol. 101, No. 1, pp. 101-103 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Brief report Acute sickle cell hepatopathy represents a potential contraindication for percutaneous liver biopsy Nada Zakaria, Alex Knisely, Bernard Portmann, Giorgina Mieli-Vergani, Julia Wendon, Roopen Arya, and John Devlin From the Institute of Liver Studies and the Department of Haematological Medicine, King's College Hospital, London, United Kingdom. After several complications following percutaneous liver biopsy in patients with sickle cell disease, we reviewed our experience. We examined 14 patients with sickle cell disease who underwent a percutaneous liver biopsy. Clinicopathologic findings were correlated with outcome. Of 14 patients, 5 (36%) suffered serious hemorrhage; 4 died (80%; 28% of all patients). None of the 9 patients without biopsy complications was in an acute sickling crisis at the time of biopsy; 4 of 5 patients with complications were in acute sickling crisis. Of the 5 patients with complications, 4 underwent biopsy for an emergency indication. Chronic venous outflow obstruction, marked hepatic sequestration of erythrocytes, and sinusoidal dilatation were strongly associated with complications. Data obtained by biopsy in group 1 were not of substantial value in clinical management, in contrast to group 2 (8/9; 89%). Acute hepatic disease complicating sickle cell anemia represents a newly identified contraindication to percutaneous liver biopsy. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. V. Adamkiewicz, M. R. Abboud, C. Paley, N. Olivieri, M. Kirby-Allen, E. Vichinsky, J. F. Casella, O. A. Alvarez, J. C. Barredo, M. T. Lee, et al. Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury Blood, November 19, 2009; 114(21): 4632 - 4638. [Abstract] [Full Text] [PDF] S. N. Kip, L. W. Hunter, Q. Ren, P. C. Harris, S. Somlo, V. E. Torres, G. C. Sieck, and Q. Qian [Ca2+]i Reduction Increases Cellular Proliferation and Apoptosis in Vascular Smooth Muscle Cells: Relevance to the ADPKD Phenotype Circ. Res., April 29, 2005; 96(8): 873 - 880. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020