|
|
Prepublished online as a Blood First Edition Paper on August 15, 2002; DOI 10.1182/blood-2002-04-1164.
 Previous Article | Table of Contents | Next Article 
Blood, 1 January 2003, Vol. 101, No. 1, pp. 143-150
HEMATOPOIESIS
Interferon- switches monocyte differentiation from
dendritic cells to macrophages
Yves Delneste,
Peggy Charbonnier,
Nathalie Herbault,
Giovanni Magistrelli,
Gersende Caron,
Jean-Yves Bonnefoy, and
Pascale Jeannin
From the Department of Biology, Centre d'Immunologie
Pierre Fabre, Saint Julien en Genevois, France.
Human monocytes differentiate into dendritic cells (DCs) or
macrophages according to the nature of environmental signals. Monocytes stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF) plus interleukin 4 (IL-4) yield DCs. We tested here
whether interferon- (IFN-), a potent activator of macrophages, may modulate monocyte differentiation. Addition of IFN- to IL-4 plus
GM-CSF-stimulated monocytes switches their differentiation from DCs to
CD14 CD64+ macrophages. IFN- increases
macrophage colony-stimulating factor (M-CSF) and IL-6 production by
IL-4 plus GM-CSF-stimulated monocytes by acting at the transcriptional
level and acts together with IL-4 to up-regulate M-CSF but not IL-6
production. IFN- also increases M-CSF receptor internalization.
Results from neutralizing experiments show that both M-CSF and IL-6 are
involved in the ability of IFN- to skew monocyte differentiation
from DCs to macrophages. Finally, this effect of IFN- is limited to
early stages of differentiation. When added to immature DCs, IFN-
up-regulates IL-6 but not M-CSF production and does not convert them to
macrophages, even in the presence of exogenous M-CSF. In conclusion,
IFN- shifts monocyte differentiation to macrophages rather than DCs through autocrine M-CSF and IL-6 production. These data show that IFN- controls the differentiation of antigen-presenting cells and
thereby reveals a new mechanism by which IFN- orchestrates the
outcome of specific immune responses.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
T. Pham, C. J. Gregg, F. Karp, R. Chow, V. Padler-Karavani, H. Cao, X. Chen, J. L. Witztum, N. M. Varki, and A. Varki
Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium
Blood,
December 10, 2009;
114(25):
5225 - 5235.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hiasa, M. Abe, A. Nakano, A. Oda, H. Amou, S. Kido, K. Takeuchi, K. Kagawa, K. Yata, T. Hashimoto, et al.
GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-{alpha} converting enzyme (TACE)
Blood,
November 12, 2009;
114(20):
4517 - 4526.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Eljaafari, Y.-P. Li, and P. Miossec
IFN-{gamma}, as Secreted during an Alloresponse, Induces Differentiation of Monocytes into Tolerogenic Dendritic Cells, Resulting in FoxP3+ Regulatory T Cell Promotion
J. Immunol.,
September 1, 2009;
183(5):
2932 - 2945.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Ibeas, L. Fuentes, R. Martin, M. Hernandez, and M. L. Nieto
Secreted phospholipase A2 type IIA as a mediator connecting innate and adaptive immunity: new role in atherosclerosis
Cardiovasc Res,
January 1, 2009;
81(1):
54 - 63.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. S. Deepe Jr, R. S. Gibbons, and A. G. Smulian
Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs
J. Leukoc. Biol.,
September 1, 2008;
84(3):
669 - 678.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Netea, E. C. Lewis, T. Azam, L. A. B. Joosten, J. Jaekal, S.-Y. Bae, C. A. Dinarello, and S.-H. Kim
Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
PNAS,
March 4, 2008;
105(9):
3515 - 3520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. E. Potts, M. L. Hart, L. L. Snyder, D. Boyle, D. A. Mosier, and S. K. Chapes
Differentiation of C2D Macrophage Cells after Adoptive Transfer
Clin. Vaccine Immunol.,
February 1, 2008;
15(2):
243 - 252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rydstrom and M. J. Wick
Monocyte Recruitment, Activation, and Function in the Gut-Associated Lymphoid Tissue during Oral Salmonella Infection
J. Immunol.,
May 1, 2007;
178(9):
5789 - 5801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Overbergh, K. Stoffels, M. Waer, A. Verstuyf, R. Bouillon, and C. Mathieu
Immune Regulation of 25-Hydroxyvitamin D-1{alpha}-Hydroxylase in Human Monocytic THP1 Cells: Mechanisms of Interferon-{gamma}-Mediated Induction
J. Clin. Endocrinol. Metab.,
September 1, 2006;
91(9):
3566 - 3574.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sanarico, A. Ciaramella, A. Sacchi, D. Bernasconi, P. Bossu, F. Mariani, V. Colizzi, and S. Vendetti
Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response
J. Leukoc. Biol.,
September 1, 2006;
80(3):
555 - 562.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Vakkila, R. Jaffe, M. Michelow, and M. T. Lotze
Pediatric cancers are infiltrated predominantly by macrophages and contain a paucity of dendritic cells: a major nosologic difference with adult tumors.
Clin. Cancer Res.,
April 1, 2006;
12(7):
2049 - 2054.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Delgado, E. Gonzalez-Rey, and D. Ganea
The Neuropeptide Vasoactive Intestinal Peptide Generates Tolerogenic Dendritic Cells
J. Immunol.,
December 1, 2005;
175(11):
7311 - 7324.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ostrowski, M. Vermeulen, O. Zabal, J. R. Geffner, A. M. Sadir, and O. J. Lopez
Impairment of Thymus-Dependent Responses by Murine Dendritic Cells Infected with Foot-and-Mouth Disease Virus
J. Immunol.,
September 15, 2005;
175(6):
3971 - 3979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-X. Jiang, Y. Zhang, B. Liu, S.-X. Zhang, Y. Wu, X.-D. Yu, and N. Mao
Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
Blood,
May 15, 2005;
105(10):
4120 - 4126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Bakri, S. Sarrazin, U. P. Mayer, S. Tillmanns, C. Nerlov, A. Boned, and M. H. Sieweke
Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate
Blood,
April 1, 2005;
105(7):
2707 - 2716.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. H. Bergman, K. D. Passalacqua, R. Gaspard, L. M. Shetron-Rama, J. Quackenbush, and P. C. Hanna
Murine Macrophage Transcriptional Responses to Bacillus anthracis Infection and Intoxication
Infect. Immun.,
February 1, 2005;
73(2):
1069 - 1080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Martino, A. Sacchi, N. Sanarico, F. Spadaro, C. Ramoni, A. Ciaramella, L. P. Pucillo, V. Colizzi, and S. Vendetti
Dendritic cells derived from BCG-infected precursors induce Th2-like immune response
J. Leukoc. Biol.,
October 1, 2004;
76(4):
827 - 834.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. H. Wu, C. N. Pabin, Z. Qin, T. Blankenstein, M. Philip, J. Dignam, K. Schreiber, and H. Schreiber
Long-Term Suppression of Tumor Growth by TNF Requires a Stat1- and IFN Regulatory Factor 1-Dependent IFN-{gamma} Pathway but Not IL-12 or IL-18
J. Immunol.,
March 1, 2004;
172(5):
3243 - 3251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Jackson, C.-R. Yu, R. M. Mahdi, S. Ebong, and C. E. Egwuagu
Dendritic Cell Maturation Requires STAT1 and Is under Feedback Regulation by Suppressors of Cytokine Signaling
J. Immunol.,
February 15, 2004;
172(4):
2307 - 2315.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
