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Prepublished online as a Blood First Edition Paper on January 23, 2003; DOI 10.1182/blood-2002-08-2673. This Article Full Text Full Text (PDF) Supplemental Methods and Table All Versions of this Article: 2002-08-2673v1 101/10/4013    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Underhill, G. H. Articles by Kansas, G. S. Search for Related Content PubMed PubMed Citation Articles by Underhill, G. H. Articles by Kansas, G. S. Related Collections Immunobiology Gene Expression Genomics Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 May 2003, Vol. 101, No. 10, pp. 4013-4021 IMMUNOBIOLOGY Gene expression profiling reveals a highly specialized genetic program of plasma cells Gregory H. Underhill, David George, Eric G. Bremer, and Geoffrey S. Kansas From the Department of Biomedical Engineering, Northwestern University, Evanston, IL; the Pediatric Brain Tumor Research Program, Department of Neurological Surgery, Northwestern University Medical School and Children's Memorial Institute of Education and Research, Chicago, IL; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL; and the Department of Microbiology-Immunology, Northwestern Medical School, Chicago, IL. The formation of terminally differentiated plasma cells represents the critical final step in B-cell differentiation. In this study, utilizing oligonucleotide microarray analysis, we describe the highly specialized genetic profile exhibited by terminally differentiated plasma cells. A total of 1476 known genes were differentially expressed by plasma cells compared with B cells. Plasma cells displayed an up-regulation, induction, or a selective retention of a unique constellation of transcription factors, including members of the AP-1, nuclear factor-B (NF-B), nuclear factor of activated T cells (NFAT), and octamer binding factor families. Interestingly, plasma cells also displayed a down-regulation of several RNA polymerase I- related factors, consistent with terminal differentiation, and exhibited a down-regulation of the TATA box binding protein. Furthermore, plasma cells displayed alterations in multiple components of the Wnt and Notch signaling pathways and showed a unique pattern of apoptosis and proliferation-associated genes. Unexpectedly, plasma cells displayed an up-regulation of 2 factors normally associated with microenvironmental positioning of neuronal cells, reelin and neuropilin-1. These results supply insight into the developmental genetics of plasma cell differentiation and provide a foundation for further analysis of plasma cell biology. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. E. Khuda, W. M. Loo, S. Janz, B. Van Ness, and L. D. Erickson Deregulation of c-Myc Confers Distinct Survival Requirements for Memory B Cells, Plasma Cells, and Their Progenitors J. Immunol., December 1, 2008; 181(11): 7537 - 7549. [Abstract] [Full Text] [PDF] C. Watanabe, G. L. Shu, T. S. Zheng, R. A. Flavell, and E. A. Clark Caspase 6 Regulates B Cell Activation and Differentiation into Plasma Cells J. Immunol., November 15, 2008; 181(10): 6810 - 6819. 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