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Prepublished online as a Blood First Edition Paper on January 16, 2003; DOI 10.1182/blood-2002-10-3090. This Article Full Text Full Text (PDF) Supplemental Data Set All Versions of this Article: 2002-10-3090v1 101/10/4115    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Klein, U. Articles by Carbone, A. Search for Related Content PubMed PubMed Citation Articles by Klein, U. Articles by Carbone, A. Related Collections Neoplasia Gene Expression Genomics Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 May 2003, Vol. 101, No. 10, pp. 4115-4121 NEOPLASIA Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts Ulf Klein, Annunziata Gloghini, Gianluca Gaidano, Amy Chadburn, Ethel Cesarman, Riccardo Dalla-Favera, and Antonino Carbone From the Institute for Cancer Genetics, and the Departments of Pathology and Genetics and Development, Columbia University, New York, NY; Division of Pathology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy; Hematology Unit, Division of Internal Medicine, Department of Medical Sciences and Interdisciplinary Research Center on Autoimmune Diseases (IRCAD), Amedeo Avogadro University of Eastern Piedmont, Novara, Italy; and Department of Pathology, Weill Medical College of Cornell University, New York, NY. AIDS-related primary effusion lymphoma (PEL) is an HIV-associated malignancy characterized by the ability of the tumor cells to specifically home in the serous body cavities. Here we used gene expression profile analysis (about 12 000 genes) to further define the phenotype of PEL and to investigate the lymphoma relationship to normal B cells and to other tumor subtypes, including non-Hodgkin lymphomas (NHLs) of immunocompetent hosts and AIDS-associated NHL (AIDS-NHL). The results showed that PEL displayed a common gene expression profile that is clearly distinct from all NHLs of immunocompetent hosts and AIDS-NHL subtypes and, in contrast to those, is not related to germinal center (GC) or memory B cells. The gene expression profile of PEL was defined as plasmablastic because it showed features of both immunoblasts identified by Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and AIDS immunoblastic lymphoma, and plasma cells, as defined by multiple myeloma cell lines. Finally, our results identify a set of genes specifically expressed in PEL tumor cells. Their expression was validated at the protein level, suggesting their potential pathogenetic and clinical significance. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: O. Balague, A. Mozos, D. Martinez, L. Hernandez, L. Colomo, J. L. Mate, J. Teruya-Feldstein, O. Lin, E. Campo, A. Lopez-Guillermo, et al. Activation of the Endoplasmic Reticulum Stress-Associated Transcription Factor X Box-Binding Protein-1 Occurs in a Subset of Normal Germinal-Center B Cells and in Aggressive B-Cell Lymphomas with Prognostic Implications Am. J. Pathol., June 1, 2009; 174(6): 2337 - 2346. [Abstract] [Full Text] [PDF] D. L. Di Bartolo, E. Hyjek, S. Keller, I. Guasparri, H. Deng, R. Sun, A. Chadburn, D. M. Knowles, and E. 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