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 Prepublished online as a Blood First Edition Paper on January 30, 2003; DOI 10.1182/blood-2002-08-2550.

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Blood, 15 June 2003, Vol. 101, No. 12, pp. 4708-4710

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Brief report

A unique atrial primary cardiac lymphoma mimicking myxoma presenting with embolic stroke: a case report

Michael M. Quigley, Eric Schwartzman, Pamela D. Boswell, Rebecca L. Christensen, Lisa A. Gleason, Robert W. Sharpe, and Thomas A. d'Amato

From the Department of Pathology, Division of Cardiology, and Division of Cardiothoracic Surgery, Naval Medical Center, San Diego; and the Department of Pathology, Scripps Clinic, La Jolla, CA.

An immunocompetent 29-year-old male presented with an embolic stroke from an unusual primary cardiac lymphoma. The cardiac lesion consisted of a polypoid, left atrial, mural fibrin thrombus with anaplastic tumor cells lining the surface of the clot. Histologic, immunophenotypic, and molecular characterizations were consistent with a diagnosis of CD30+ large B-cell lymphoma with anaplastic cytology. While tumor emboli from invasive primary cardiac lymphomas have been reported, this noninvasive fibrin thrombus–associated lymphoma appears to be unique and previously unreported.


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