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Prepublished online as a Blood First Edition Paper on March 6, 2003; DOI 10.1182/blood-2002-12-3802. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-12-3802v1 101/12/4850    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gris, J.-C. Articles by Marès, P. Search for Related Content PubMed PubMed Citation Articles by Gris, J.-C. Articles by Marès, P. Related Collections Hemostasis, Thrombosis, and Vascular Biology Immunobiology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 June 2003, Vol. 101, No. 12, pp. 4850-4852 HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report Anti–protein Z antibodies in women with pathologic pregnancies Jean-Christophe Gris, Cécile Amadio, Eric Mercier, Géraldine Lavigne-Lissalde, Hervé Déchaud, Médéric Hoffet, Isabelle Quéré, Jean Amiral, Michel Dauzat, and Pierre Marès From the Laboratoire d'Hématologie, Unité de Formation et de Recherche (UFR) des sciences pharmaceutiques et biologiques, Université Montpellier 1, Montpellier, France; Laboratoire d'Hématologie, Centre Hospitalier Universitaire (CHU) de Nîmes, France; the EA 2992 ("Dynamique des incohérences cardiovasculaires"), Nîmes, France; the Département de Gynécologie et Obstétrique, CHU de Nîmes, France; and Hyphen BioMed, Andrésy; France. Protein Z deficiencies have recently been described in women with unexplained early fetal loss. Using a new, specifically elaborated, commercially available enzyme-linked immunosorbent assay (ELISA), we performed a case-control study on anti–protein Z immunoglobulin G (IgG) and IgM antibodies in 191 nonthrombotic, nonthrombophilic women with consecutive pathologic pregnancies. Levels of anti–protein Z antibodies were categorized in 3 strata (percentiles 1 through 74, 75 through 97, 98 through 100 among controls). The 2 upper levels of IgG and IgM anti–protein Z antibodies were associated with the risk of unexplained recurrent embryo loss or fetal death independently from habitual antiphospholipid/anticofactor antibodies, and a dose-effect relationship between antibody levels and the clinical risks was evidenced. In women, enhanced immune-complex formation with protein Z may play a role in unexplained embryo losses and, from the 10th week of gestation, may favor hypercoagulability in the maternal placenta side. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. M. Abo and V. A. DeBari Laboratory Evaluation of the Antiphospholipid Syndrome Ann. Clin. Lab. Sci., January 1, 2007; 37(1): 3 - 14. [Abstract] [Full Text] [PDF] M. Bern Observations on Possible Effects of Daily Vitamin K Replacement, Especially Upon Warfarin Therapy JPEN J Parenter Enteral Nutr, November 1, 2004; 28(6): 388 - 398. [Abstract] [Full Text] [PDF] V. Hurtado, R. Montes, J.-C. Gris, M. L. Bertolaccini, A. Alonso, M. A. Martinez-Gonzalez, M. A. Khamashta, K. Fukudome, D. A. Lane, and J. Hermida Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death Blood, September 1, 2004; 104(5): 1369 - 1374. [Abstract] [Full Text] [PDF] J.-C. Gris, E. Mercier, I. Quere, G. Lavigne-Lissalde, E. Cochery-Nouvellon, M. Hoffet, S. Ripart-Neveu, M.-L. Tailland, M. Dauzat, and P. Mares Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder Blood, May 15, 2004; 103(10): 3695 - 3699. [Abstract] [Full Text] [PDF]

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