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Prepublished online as a Blood First Edition Paper on September 19, 2002; DOI 10.1182/blood-2002-07-1957. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-07-1957v1 101/3/1024    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mueller, Y. M. Articles by Katsikis, P. D. Search for Related Content PubMed PubMed Citation Articles by Mueller, Y. M. Articles by Katsikis, P. D. Related Collections Immunobiology Apoptosis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 February 2003, Vol. 101, No. 3, pp. 1024-1029 IMMUNOBIOLOGY IL-15 enhances survival and function of HIV-specific CD8+ T cells Yvonne M. Mueller, Paul M. Bojczuk, E. Scott Halstead, Alfred H. J. Kim, James Witek, John D. Altman, and Peter D. Katsikis From the Department of Microbiology and Immunology and Department of Medicine, Drexel University College of Medicine, Drexel University, Philadelphia, PA; and Department of Microbiology and Immunology, Emory University, Atlanta, GA. HIV-specific CD8+ T cells are prone to undergo apoptosis, and this may affect their ability to control HIV infection. Because CD8-mediated immune responses play a key role in controlling HIV infection, enhancing the survival and effector function of HIV-specific CD8+ T cells may augment their ability to control HIV virus. We show here that interleukin 15 (IL-15) potently inhibits spontaneous and CD95/Fas-induced apoptosis of HIV-specific CD8+ T cells. IL-15 inhibits apoptosis in both CD45RACD62L and CD45RA+CD62L effector memory subpopulations of these cells. Furthermore, IL-15 greatly enhances the survival of HIV-specific CD8+ T cells in long-term cultures. Finally, IL-15 directly enhances activation, interferon  (IFN) production, and direct ex vivo cytotoxicity of HIV-specific CD8+ T cells. Thus, IL-15 potently enhances the survival and effector function of HIV-specific CD8+ T cells and, therefore, may prove useful in augmenting the antiviral function of these cells. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. I. Kokaji, D. L. Hockley, and K. P. 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