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Prepublished online as a Blood First Edition Paper on September 12, 2002; DOI 10.1182/blood-2002-05-1392.
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Blood, 1 February 2003, Vol. 101, No. 3, pp. 846-848
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Brief report
Nocturnal oxygen saturation and painful sickle cell crises
in children
Darren R. Hargrave,
Angie Wade,
Jane P. M. Evans,
Deborah K. M. Hewes, and
Fenella J. Kirkham
From the Department of Paediatric Epidemiology and
Biostatistics and from the Neurosciences Unit, Institute of Child
Health; Great Ormond Street Hospital; and Department of Haematology,
University College Hospital; all of London, United Kingdom; and
Paediatric Oncology Unit, The Royal Marsden Hospital, Sutton,
United Kingdom.
The pathogenesis of acute painful crisis in children with sickle
cell disease is poorly understood; suggested risk factors include
sickle cell type, severity of anemia, fetal hemoglobin concentration,
and hypoxemia from upper airway obstruction. In a cohort study of 95 patients the relationship between clinical, laboratory, and sleep study
data and frequency of painful crisis was investigated. Both univariate
and multiple regression modeling showed that low nocturnal oxygen
saturation was highly significantly associated with a higher rate of
painful crisis in childhood (P < .0001). Screening and
treatment for hypoxemia may reduce the frequency of this and other
complications of the disease.
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