|
|
Prepublished online as a Blood First Edition Paper on September 26, 2002; DOI 10.1182/blood-2002-05-1416.
 Previous Article | Table of Contents | Next Article 
Blood, 15 February 2003, Vol. 101, No. 4, pp. 1243-1248
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Fibrin fragment D-dimer and the risk of future venous
thrombosis
Mary Cushman,
Aaron R. Folsom,
Lu Wang,
Nena Aleksic,
Wayne D. Rosamond,
Russell P. Tracy, and
Susan R. Heckbert
From the Laboratory for Clinical Biochemistry Research
and Departments of Medicine, Pathology, and Biochemistry, University of
Vermont, Colchester; Division of Epidemiology, School of Public Health,
University of Minnesota, Minneapolis; Department of Internal Medicine,
University of Texas, Houston; Department of Epidemiology, University of
North Carolina, Chapel Hill; and Department of Epidemiology, University
of Washington, Seattle.
Plasma D-dimer concentration rises more than 100-fold
during acute deep vein thrombosis, but there are no prospective data concerning D-dimer as a risk factor for incident venous thrombosis in a
general population. Incident venous thrombosis was ascertained in 2 prospective observational studies, the Atherosclerosis Risk in
Communities Study and the Cardiovascular Health Study. Of 21 690
participants enrolled between 1987 and 1993, after 8 years of
follow-up, D-dimer was measured using baseline stored plasma of 307 participants who developed venous thrombosis and 616 who did not.
Relative to the first quintile of the distribution of D-dimer, the
age-adjusted odds ratios for future venous thrombosis for the second to
fifth quintiles of D-dimer were 1.6, 2.3, 2.3, and 4.2, respectively
(P for trend < .0001). Following added adjustment for
sex, race, body mass index, factor V Leiden, prothrombin 20210A, and
elevated factor VIII coagulant activity (factor VIII:c),
these odds ratios were 1.5, 2.1, 1.9, and 3.0, respectively
(P for trend < .0001). Among those with idiopathic
thrombosis or secondary thrombosis unrelated to cancer, the adjusted
fifth quintile odds ratios were 3.5 and 4.8, respectively. By contrast,
D-dimer in the fifth versus first quintile was not related to
occurrence of cancer-associated thrombosis (odds ratio, 1.1). Odds
ratios for elevated D-dimer were consistently elevated in subgroups
defined by age, sex, race, duration of follow-up, and thrombosis type (deep vein thrombosis or pulmonary embolus). D-dimer is strongly and
positively related to the occurrence of future venous thrombosis.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Letter in Blood Online:
-
Plasma D-dimer measurement as a predictor of venous thrombosis
- Muttuswamy Sivakumaran, Neil Malton, and Mary Cushman
Blood 2003 102: 4618-4619.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
A. Undas, K. Zawilska, M. Ciesla-Dul, A. Lehmann-Kopydlowska, A. Skubiszak, K. Ciepluch, and W. Tracz
Altered fibrin clot structure/function in patients with idiopathic venous thromboembolism and in their relatives
Blood,
November 5, 2009;
114(19):
4272 - 4278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. L. Mota, M. E. R. de Castro Santos, F. d. C. Lima e Silva, N. C. de Carvalho Schachnik, M. de Oliveira Sousa, and M. das Gracas Carvalho
Hypercoagulability Markers in Patients With Peripheral Arterial Disease: Association to Ankle-brachial Index
Angiology,
October 1, 2009;
60(5):
529 - 535.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Cushman, E. S. O'Meara, A. R. Folsom, and S. R. Heckbert
Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology
Blood,
October 1, 2009;
114(14):
2878 - 2883.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Ay, R. Vormittag, D. Dunkler, R. Simanek, A.-L. Chiriac, J. Drach, P. Quehenberger, O. Wagner, C. Zielinski, and I. Pabinger
D-Dimer and Prothrombin Fragment 1 + 2 Predict Venous Thromboembolism in Patients With Cancer: Results From the Vienna Cancer and Thrombosis Study
J. Clin. Oncol.,
September 1, 2009;
27(25):
4124 - 4129.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.-W. Kang, S.-H. Yoo, S. Chun, K.-Y. Kwon, S. U. Kwon, J.-Y. Koh, and J. S. Kim
Inflammatory and Hemostatic Biomarkers Associated With Early Recurrent Ischemic Lesions in Acute Ischemic Stroke
Stroke,
May 1, 2009;
40(5):
1653 - 1658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Pabinger and C. Ay
Biomarkers and Venous Thromboembolism
Arterioscler Thromb Vasc Biol,
March 1, 2009;
29(3):
332 - 336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Verhovsek, J. D. Douketis, Q. Yi, S. Shrivastava, R. C. Tait, T. Baglin, D. Poli, and W. Lim
Systematic Review: D-Dimer to Predict Recurrent Disease after Stopping Anticoagulant Therapy for Unprovoked Venous Thromboembolism
Ann Intern Med,
October 7, 2008;
149(7):
481 - 490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. L. Silverstein, K. A. Bauer, M. Cushman, C. T. Esmon, W. B. Ershler, and R. P. Tracy
Venous thrombosis in the elderly: more questions than answers
Blood,
November 1, 2007;
110(9):
3097 - 3101.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Steffen, A. R. Folsom, M. Cushman, D. R. Jacobs Jr, and W. D. Rosamond
Greater Fish, Fruit, and Vegetable Intakes Are Related to Lower Incidence of Venous Thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology
Circulation,
January 16, 2007;
115(2):
188 - 195.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Folsom, L. L. Boland, M. Cushman, S. R. Heckbert, W. D. Rosamond, and J. D. Walston
Frailty and Risk of Venous Thromboembolism in Older Adults
J. Gerontol. A Biol. Sci. Med. Sci.,
January 1, 2007;
62(1):
79 - 82.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Heit
Thrombophilia: Common Questions on Laboratory Assessment and Management
Hematology,
January 1, 2007;
2007(1):
127 - 135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Scarvelis and P. S. Wells
Diagnosis and treatment of deep-vein thrombosis.
Can. Med. Assoc. J.,
October 24, 2006;
175(9):
1087 - 1092.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hemelaar, J. Rosing, P. Kenemans, M. C. L.G.D. Thomassen, D. D.M. Braat, and M. J. van der Mooren
Less Effect of Intranasal Than Oral Hormone Therapy on Factors Associated With Venous Thrombosis Risk in Healthy Postmenopausal Women
Arterioscler Thromb Vasc Biol,
July 1, 2006;
26(7):
1660 - 1666.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Le Gal, M. Righini, P.-M. Roy, O. Sanchez, D. Aujesky, A. Perrier, and H. Bounameaux
Value of D-Dimer Testing for the Exclusion of Pulmonary Embolism in Patients With Previous Venous Thromboembolism
Arch Intern Med,
January 23, 2006;
166(2):
176 - 180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Cushman
Inherited Risk Factors for Venous Thrombosis
Hematology,
January 1, 2005;
2005(1):
452 - 457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Prandoni
Acquired Risk Factors for Venous Thromboembolism in Medical Patients
Hematology,
January 1, 2005;
2005(1):
458 - 461.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Nowak-Gottl and A. Kosch
Factor VIII, D-Dimer, and Thromboembolism in Children
N. Engl. J. Med.,
September 9, 2004;
351(11):
1051 - 1053.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sivakumaran, N. Malton, and M. Cushman
Plasma D-dimer measurement as a predictor of venous thrombosis
Blood,
December 15, 2003;
102(13):
4618 - 4619.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Eichinger, E. Minar, C. Bialonczyk, M. Hirschl, P. Quehenberger, B. Schneider, A. Weltermann, O. Wagner, and P. A. Kyrle
D-Dimer Levels and Risk of Recurrent Venous Thromboembolism
JAMA,
August 27, 2003;
290(8):
1071 - 1074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
