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Prepublished online as a Blood First Edition Paper on October 31, 2002; DOI 10.1182/blood-2002-06-1837. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-06-1837v1 101/6/2307    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Högerkorp, C.-M. Articles by Borrebaeck, C. A. K. Search for Related Content PubMed PubMed Citation Articles by Högerkorp, C.-M. Articles by Borrebaeck, C. A. K. Related Collections Immunobiology Apoptosis Cell Adhesion and Motility Signal Transduction Gene Expression Genomics Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 March 2003, Vol. 101, No. 6, pp. 2307-2313 IMMUNOBIOLOGY CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays Carl-Magnus Högerkorp, Sven Bilke, Thomas Breslin, Sigurdur Ingvarsson, and Carl A. K. Borrebaeck From the Department of Immunotechnology, Lund University, Sweden; and Department of Complex Systems, Lund University, Sweden. A number of studies have implicated a role for the cell surface glycoprotein CD44 in several biologic events, such as lymphopoiesis, homing, lymphocyte activation, and apoptosis. We have earlier reported that signaling via CD44 on naive B cells in addition to B-cell receptor (BCR) and CD40 engagement generated a germinal center-like phenotype. To further characterize the global role of CD44 in B differentiation, we examined the expression profile of human B cells cultured in vitro in the presence or absence of CD44 ligation, together with anti-immunoglobulin (anti-Ig) and anti-CD40 antibodies. The data sets derived from DNA microarrays were analyzed using a novel statistical analysis scheme created to retrieve the most likely expression pattern of CD44 ligation. Our results show that genes such as interleukin-6 (IL-6), IL-1, and 2-adrenergic receptor (2-AR) were specifically up-regulated by CD44 ligation, suggesting a novel role for CD44 in immunoregulation and inflammation. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Higuchi, F. O. Bartel, M. Masuya, T. Deguchi, K. W. Henderson, R. Li, R. C. Muise-Helmericks, M. J. Kern, D. K. Watson, and D. D. Spyropoulos Thymomegaly, Microsplenia, and Defective Homeostatic Proliferation of Peripheral Lymphocytes in p51-Ets1 Isoform-Specific Null Mice Mol. Cell. Biol., May 1, 2007; 27(9): 3353 - 3366. [Abstract] [Full Text] [PDF] M. Montano, M. Rarick, P. Sebastiani, P. Brinkmann, J. Skefos, and R. Ericksen HIV-1 burden influences host response to co-infection with Neisseria gonorrhoeae in vitro Int. Immunol., January 1, 2006; 18(1): 125 - 137. [Abstract] [Full Text] [PDF] L. Li, S.-O. Yoon, D.-D. Fu, X. Zhang, and Y. S. Choi Novel follicular dendritic cell molecule, 8D6, collaborates with CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055 Blood, August 1, 2004; 104(3): 815 - 821. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020