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Prepublished online as a Blood First Edition Paper on December 19, 2002; DOI 10.1182/blood-2002-08-2638. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-08-2638v1 101/8/3106    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Masci, A. M. Articles by Racioppi, L. Search for Related Content PubMed PubMed Citation Articles by Masci, A. M. Articles by Racioppi, L. Related Collections Immunobiology Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 April 2003, Vol. 101, No. 8, pp. 3106-3108 IMMUNOBIOLOGY Brief report Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia Anna Maria Masci, Giovannella Palmieri, Laura Vitiello, Liliana Montella, Francesco Perna, Paola Orlandi, Gianfranco Abbate, Serafino Zappacosta, Raffaele De Palma, and Luigi Racioppi From the Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Italy; the Dipartimento di Oncologia molecolare e clinica, Federico II University of Naples, Italy; the Laboratorio di Microbiologia e Chimica Clinica, Monaldi Hospital, Naples, Italy; the Divisione di Immunologia e Malattie Infettive, Ospedale Bambin Gesù, "Tor Vergata" University of Rome, Rome, Italy; and the Dipartimento di Inernistica Clinica e Sperimentale, Second University of Naples, Naples, Italy. A subgroup of thymoma patients is affected by severe immunodeficiency clinically resembling an HIV infection (Good syndrome). These individuals are characterized by B lymphopenia with B-lymphopoiesis deficiency. To investigate the pathogenesis of this unique condition, we studied the T-cell repertoire in blood and bone marrow samples by heterogeneity length analysis of CDR3 beta variable regions of the T-cell receptor (spectratyping). While no alterations were found in the peripheral blood, we detected an oligoclonal population of  variable 8 (BV8) CD8+ T cells in 5 of 5 bone marrow samples. No lymphocyte expansions were found in the bone marrow of 2 thymoma patients with normal B-cell counts, 2 healthy donors, and 3 patients with diseases unrelated to thymoma. These data suggest that an immune response toward an unknown antigen is taking place in the bone marrow of B-lymphopenic thymoma patients. We propose that BV8 CD8+ T cells may play a role in the pathogenesis of this immunodeficiency syndrome. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. de Laurentiis, L. Vitiello, L. Racioppi, F. Perna, M. Galgani, G. Merola, P. Carratu, M. Maniscalco, S. Marsico, and M. Sofia CD8+ T-cell alveolitis in familial pulmonary alveolar microlithiasis Eur. Respir. J., July 1, 2007; 30(1): 165 - 171. [Abstract] [Full Text] [PDF] P. Striano, F. Tortora, A. Evoli, G. Palmieri, A. Elefante, F. Zara, P. E. Tarr, and S. Striano Periodic Myoclonus Due to Cytomegalovirus Encephalitis in a Patient With Good Syndrome Arch Neurol, February 1, 2007; 64(2): 277 - 279. [Abstract] [Full Text] [PDF] R. De Palma, F. Del Galdo, G. Abbate, M. Chiariello, R. Calabro, L. Forte, G. Cimmino, M. F. Papa, M. G. Russo, G. Ambrosio, et al. Patients With Acute Coronary Syndrome Show Oligoclonal T-Cell Recruitment Within Unstable Plaque: Evidence for a Local, Intracoronary Immunologic Mechanism Circulation, February 7, 2006; 113(5): 640 - 646. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020