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Prepublished online as a Blood First Edition Paper on January 2, 2003; DOI 10.1182/blood-2002-10-3063.
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Blood, 1 May 2003, Vol. 101, No. 9, pp. 3520-3526
IMMUNOBIOLOGY
Activation of influenza virus-specific CD4+ and
CD8+ T cells: a new role for plasmacytoid dendritic
cells in adaptive immunity
Jean-François Fonteneau,
Michel Gilliet,
Marie Larsson,
Ida Dasilva,
Christian Münz,
Yong-Jun Liu, and
Nina Bhardwaj
From the Laboratory of Molecular Neuro-Oncology, and
the Laboratory of Cellular Physiology and Immunology, Rockefeller
University, New York, NY; and the Department of Immunology,
DNAX Research Institute, Palo Alto, CA.
Plasmacytoid dendritic cells (pDCs) contribute to innate
antiviral immune responses by producing type I interferons
(IFNs) upon exposure to enveloped viruses. However, their role
in adaptive immune responses, such as the initiation of antiviral
T-cell responses, is not known. In this study, we examined interactions
between blood pDCs and influenza virus with special attention to the
capacity of pDCs to activate influenza-specific T cells. pDCs were
compared with CD11c+ DCs, the most potent
antigen-presenting cells (APCs), for their capacity to activate
T-cell responses. We found that like CD11c+ DCs,
pDCs mature following exposure to influenza virus, express CCR7, and
produce proinflammatory chemokines, but differ in that they produce
type I IFN and are resistant to the cytopathic effect of the infection.
After influenza virus exposure, both DC types exhibited an equivalent
efficiency to expand anti-influenza virus cytotoxic T lymphocytes
(CTLs) and T helper 1 (TH1) CD4+ T cells.
Our results pinpoint a new role of pDCs in the induction of antiviral
T-cell responses and suggest that these DCs play a prominent role in
the adaptive immune response against viruses.
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