SEARCH:   Advanced

Blood, 15 November 2003, Vol. 102, No. 10, pp. 3483-3493. Prepublished online as a Blood First Edition Paper on July 31, 2003; DOI 10.1182/blood-2003-05-1664. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-05-1664v1 102/10/3483    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Herzog, E. L. Articles by Krause, D. S. Search for Related Content PubMed PubMed Citation Articles by Herzog, E. L. Articles by Krause, D. S. Related Collections Hematopoiesis and Stem Cells Transplantation Reviews in Translational Hematology Gene Therapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW IN TRANSLATIONAL HEMATOLOGY Plasticity of marrow-derived stem cells Erica L. Herzog, Li Chai, and Diane S. Krause From the Departments of Medicine and Laboratory Medicine, Yale University School of Medicine, New Haven, CT. Bone marrow (BM) contains hematopoietic stem cells (HSCs), which differentiate into every type of mature blood cell; endothelial cell progenitors; and marrow stromal cells, also called mesenchymal stem cells (MSCs), which can differentiate into mature cells of multiple mesenchymal tissues including fat, bone, and cartilage. Recent findings indicate that adult BM also contains cells that can differentiate into additional mature, nonhematopoietic cells of multiple tissues including epithelial cells of the liver, kidney, lung, skin, gastrointestinal (GI) tract, and myocytes of heart and skeletal muscle. Experimental results obtained in vitro and in vivo are the subject of this review. The emphasis is on how these experiments were performed and under what conditions differentiation from bone marrow to epithelial and neural cells occurs. Questions arise regarding whether tissue injury is necessary for this differentiation and the mechanisms by which it occurs. We also consider which bone marrow subpopulations are capable of this differentiation. Only after we have a better understanding of the mechanisms involved and of the cells required for this differentiation will we be able to fully harness adult stem cell plasticity for clinical purposes. (Blood. 2003; 102:3483-3493) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Haridass, Q. Yuan, P. D. Becker, T. Cantz, M. Iken, M. Rothe, N. Narain, M. Bock, M. Norder, N. Legrand, et al. Repopulation Efficiencies of Adult Hepatocytes, Fetal Liver Progenitor Cells, and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice Am. J. Pathol., October 1, 2009; 175(4): 1483 - 1492. [Abstract] [Full Text] [PDF] J. A. Fritzell Jr., Q. Mao, S. Gundavarapu, T. Pasquariello, J. M. Aliotta, A. Ayala, J. F. Padbury, and M. E. De Paepe Fate and Effects of Adult Bone Marrow Cells in Lungs of Normoxic and Hyperoxic Newborn Mice Am. J. Respir. Cell Mol. Biol., May 1, 2009; 40(5): 575 - 587. [Abstract] [Full Text] [PDF] S. R. Umansky From Transrenal DNA to Stem Cell Differentiation: An Unexpected Twist Clin. Chem., April 1, 2009; 55(4): 602 - 604. [Full Text] [PDF] C. Nern, I. Wolff, J. Macas, J. von Randow, C. Scharenberg, J. Priller, and S. Momma Fusion of Hematopoietic Cells with Purkinje Neurons Does Not Lead to Stable Heterokaryon Formation under Noninvasive Conditions J. Neurosci., March 25, 2009; 29(12): 3799 - 3807. [Abstract] [Full Text] [PDF] J. Xu, X. Liu, J. Chen, A. Zacharek, X. Cui, S. Savant-Bhonsale, Z. Liu, and M. Chopp Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway Am J Physiol Cell Physiol, March 1, 2009; 296(3): C535 - C543. [Abstract] [Full Text] [PDF] S. Schwarting, S. Litwak, W. Hao, M. Bahr, J. Weise, and H. Neumann Hematopoietic Stem Cells Reduce Postischemic Inflammation and Ameliorate Ischemic Brain Injury Stroke, October 1, 2008; 39(10): 2867 - 2875. [Abstract] [Full Text] [PDF] B. R. Stripp Hierarchical Organization of Lung Progenitor Cells: Is there An Adult Lung Tissue Stem Cell? Proceedings of the ATS, August 15, 2008; 5(6): 695 - 698. [Abstract] [Full Text] [PDF] J. M. Liebler, C. Lutzko, A. Banfalvi, D. Senadheera, N. Aghamohammadi, E. D. Crandall, and Z. Borok Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury Am J Physiol Lung Cell Mol Physiol, August 1, 2008; 295(2): L285 - L292. [Abstract] [Full Text] [PDF] M. P. Flaherty, A. Abdel-Latif, Q. Li, G. Hunt, S. Ranjan, Q. Ou, X.-L. Tang, R. K. Johnson, R. Bolli, and B. Dawn Noncanonical Wnt11 Signaling Is Sufficient to Induce Cardiomyogenic Differentiation in Unfractionated Bone Marrow Mononuclear Cells Circulation, April 29, 2008; 117(17): 2241 - 2252. [Abstract] [Full Text] [PDF] K.E. Schwab, P. Hutchinson, and C.E. Gargett Identification of surface markers for prospective isolation of human endometrial stromal colony-forming cells Hum. Reprod., April 1, 2008; 23(4): 934 - 943. [Abstract] [Full Text] [PDF] J. L. Spees, M. J. Whitney, D. E. Sullivan, J. A. Lasky, M. Laboy, J. Ylostalo, and D. J. Prockop Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension FASEB J, April 1, 2008; 22(4): 1226 - 1236. [Abstract] [Full Text] [PDF] L. Li, P. Truong, P. Igarashi, and F. Lin Renal and Bone Marrow Cells Fuse after Renal Ischemic Injury J. Am. Soc. Nephrol., December 1, 2007; 18(12): 3067 - 3077. [Full Text] [PDF] J. L. Spees, D. A. Pociask, D. E. Sullivan, M. J. Whitney, J. A. Lasky, D. J. Prockop, and A. R. Brody Engraftment of Bone Marrow Progenitor Cells in a Rat Model of Asbestos-Induced Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 385 - 394. [Abstract] [Full Text] [PDF] E. L. Herzog, J. Van Arnam, B. Hu, J. Zhang, Q. Chen, A. M. Haberman, and D. S. Krause Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation FASEB J, August 1, 2007; 21(10): 2592 - 2601. [Abstract] [Full Text] [PDF] K. Kato, M. Yoshimoto, K. Kato, S. Adachi, A. Yamayoshi, T. Arima, K. Asanoma, S. Kyo, T. Nakahata, and N. Wake Characterization of side-population cells in human normal endometrium Hum. Reprod., May 1, 2007; 22(5): 1214 - 1223. [Abstract] [Full Text] [PDF] Y. Lue, K. Erkkila, P. Y. Liu, K. Ma, C. Wang, A. S. Hikim, and R. S. Swerdloff Fate of Bone Marrow Stem Cells Transplanted into the Testis: Potential Implication for Men with Testicular Failure Am. J. Pathol., March 1, 2007; 170(3): 899 - 908. [Abstract] [Full Text] [PDF] B. T. Himes, B. Neuhuber, C. Coleman, R. Kushner, S. A. Swanger, G. C. Kopen, J. Wagner, J. S. Shumsky, and I. Fischer Recovery of Function Following Grafting of Human Bone Marrow-Derived Stromal Cells into the Injured Spinal Cord Neurorehabil Neural Repair, June 1, 2006; 20(2): 278 - 296. [Abstract] [PDF] L. d. S. Meirelles, P. C. Chagastelles, and N. B. Nardi Mesenchymal stem cells reside in virtually all post-natal organs and tissues J. Cell Sci., June 1, 2006; 119(11): 2204 - 2213. [Abstract] [Full Text] [PDF] D. J. Weiss, M. A. Berberich, Z. Borok, D. B. Gail, J. K. Kolls, C. Penland, and D. J. Prockop Adult Stem Cells, Lung Biology, and Lung Disease Proceedings of the ATS, May 1, 2006; 3(3): 193 - 207. [Full Text] [PDF] F. Ishikawa, H. Shimazu, L. D. Shultz, M. Fukata, R. Nakamura, B. Lyons, K. Shimoda, S. Shimoda, T. Kanemaru, K.-i. Nakamura, et al. Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion FASEB J, May 1, 2006; 20(7): 950 - 952. [Abstract] [Full Text] [PDF] Y. Yamada and N. Takakura Physiological pathway of differentiation of hematopoietic stem cell population into mural cells J. Exp. Med., April 17, 2006; 203(4): 1055 - 1065. [Abstract] [Full Text] [PDF] M. Gnecchi, H. He, N. Noiseux, O. D. Liang, L. Zhang, F. Morello, H. Mu, L. G. Melo, R. E. Pratt, J. S. Ingwall, et al. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement FASEB J, April 1, 2006; 20(6): 661 - 669. [Abstract] [Full Text] [PDF] A. Trounson The Production and Directed Differentiation of Human Embryonic Stem Cells Endocr. Rev., April 1, 2006; 27(2): 208 - 219. [Abstract] [Full Text] [PDF] R. H. Lee, S. C. Hsu, J. Munoz, J. S. Jung, N. R. Lee, R. Pochampally, and D. J. Prockop A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice Blood, March 1, 2006; 107(5): 2153 - 2161. [Abstract] [Full Text] [PDF] E. M. Bruscia, J. E. Price, E.-C. Cheng, S. Weiner, C. Caputo, E. C. Ferreira, M. E. Egan, and D. S. Krause Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation PNAS, February 21, 2006; 103(8): 2965 - 2970. [Abstract] [Full Text] [PDF] J. J. Minguell and A. Erices Mesenchymal Stem Cells and the Treatment of Cardiac Disease Experimental Biology and Medicine, January 1, 2006; 231(1): 39 - 49. [Abstract] [Full Text] [PDF] A. M. Hajjar, H. Harowicz, H. D. Liggitt, P. J. Fink, C. B. Wilson, and S. J. Skerrett An Essential Role for Non-Bone Marrow-Derived Cells in Control of Pseudomonas aeruginosa Pneumonia Am. J. Respir. Cell Mol. Biol., November 1, 2005; 33(5): 470 - 475. [Abstract] [Full Text] [PDF] V. Kindler Postnatal stem cell survival: does the niche, a rare harbor where to resist the ebb tide of differentiation, also provide lineage-specific instructions? J. Leukoc. Biol., October 1, 2005; 78(4): 836 - 844. [Abstract] [Full Text] [PDF] M. Rojas, J. Xu, C. R. Woods, A. L. Mora, W. Spears, J. Roman, and K. L. Brigham Bone Marrow-Derived Mesenchymal Stem Cells in Repair of the Injured Lung Am. J. Respir. Cell Mol. Biol., August 1, 2005; 33(2): 145 - 152. [Abstract] [Full Text] [PDF] Y. Sato, H. Araki, J. Kato, K. Nakamura, Y. Kawano, M. Kobune, T. Sato, K. Miyanishi, T. Takayama, M. Takahashi, et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion Blood, July 15, 2005; 106(2): 756 - 763. [Abstract] [Full Text] [PDF] H. K. Haider and M. Ashraf Bone marrow stem cell transplantation for cardiac repair Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2557 - H2567. [Abstract] [Full Text] [PDF] T.-C. Fang, M. R. Alison, H. T. Cook, R. Jeffery, N. A. Wright, and R. Poulsom Proliferation of Bone Marrow-Derived Cells Contributes to Regeneration after Folic Acid-Induced Acute Tubular Injury J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1723 - 1732. [Abstract] [Full Text] [PDF] C M Doerschuk Circulating endothelial progenitor cells in pulmonary inflammation Thorax, May 1, 2005; 60(5): 362 - 364. [Full Text] [PDF] J. R. Gothert, S. E. Gustin, M. A. Hall, A. R. Green, B. Gottgens, D. J. Izon, and C. G. Begley In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis Blood, April 1, 2005; 105(7): 2724 - 2732. [Abstract] [Full Text] [PDF] I. Roeder, L. M. Kamminga, K. Braesel, B. Dontje, G. de Haan, and M. Loeffler Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization Blood, January 15, 2005; 105(2): 609 - 616. [Abstract] [Full Text] [PDF] M. Stadtfeld and T. Graf Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing Development, January 1, 2005; 132(1): 203 - 213. [Abstract] [Full Text] [PDF] F. Q. Pirih, A. Tang, I. C. Ozkurt, J. M. Nervina, and S. Tetradis Nuclear Orphan Receptor Nurr1 Directly Transactivates the Osteocalcin Gene in Osteoblasts J. Biol. Chem., December 17, 2004; 279(51): 53167 - 53174. [Abstract] [Full Text] [PDF] X. Borue, S. Lee, J. Grove, E. L. Herzog, R. Harris, T. Diflo, E. Glusac, K. Hyman, N. D. Theise, and D. S. Krause Bone Marrow-Derived Cells Contribute to Epithelial Engraftment during Wound Healing Am. J. Pathol., November 1, 2004; 165(5): 1767 - 1772. [Abstract] [Full Text] [PDF] C. S. Wong and A. J. Van der Kogel MECHANISMS OF RADIATION INJURY TO THE CENTRAL NERVOUS SYSTEM: IMPLICATIONS FOR NEUROPROTECTION Mol. Interv., October 1, 2004; 4(5): 273 - 284. [Abstract] [Full Text] [PDF] M. Arriero, S. V. Brodsky, O. Gealekman, P. A. Lucas, and M. S. Goligorsky Adult skeletal muscle stem cells differentiate into endothelial lineage and ameliorate renal dysfunction after acute ischemia Am J Physiol Renal Physiol, October 1, 2004; 287(4): F621 - F627. [Abstract] [Full Text] [PDF] M. Dominici, C. Pritchard, J. E. Garlits, T. J. Hofmann, D. A. Persons, and E. M. Horwitz Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation PNAS, August 10, 2004; 101(32): 11761 - 11766. [Abstract] [Full Text] [PDF] R. G. Harris, E. L. Herzog, E. M. Bruscia, J. E. Grove, J. S. Van Arnam, and D. S. Krause Lack of a Fusion Requirement for Development of Bone Marrow-Derived Epithelia Science, July 2, 2004; 305(5680): 90 - 93. [Abstract] [Full Text] [PDF] D. C. Hess, W. D. Hill, J. E. Carroll, and C. V. Borlongan Do Bone Marrow Cells Generate Neurons? Arch Neurol, April 1, 2004; 61(4): 483 - 485. [Full Text] [PDF] B. R. Pitt and L. A. Ortiz Stem cells in lung biology Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L621 - L623. [Full Text] [PDF] K. R. Boheler Functional markers and the 'homogeneity' of human mesenchymal stem cells J. Physiol., February 1, 2004; 554(3): 592 - 592. [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020