SEARCH:   Advanced

Blood, 15 December 2003, Vol. 102, No. 13, pp. 4407-4409. Prepublished online as a Blood First Edition Paper on August 21, 2003; DOI 10.1182/blood-2003-05-1602. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-05-1602v1 102/13/4407    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tadros, A. Articles by Brindle, N. P. J. Search for Related Content PubMed PubMed Citation Articles by Tadros, A. Articles by Brindle, N. P. J. Related Collections Hemostasis, Thrombosis, and Vascular Biology Apoptosis Signal Transduction Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1 Amir Tadros, David P. Hughes, Benjamin J. Dunmore, and Nicholas P. J. Brindle From the University of Leicester Cardiovascular Research Institute and Department of Surgery, United Kingdom. A20 binding inhibitor of NF-B activation-2, ABIN-2, is a newly identified intracellular protein that interacts with the zinc finger protein A20. ABIN-2 inhibits nuclear factor-B (NF-B) activity and is a possible effector of A20 regulation of NF-B. Although A20 is a potent inhibitor of endothelial apoptosis, the effect of ABIN-2 on apoptosis is not known. ABIN-2 also interacts with the endothelial receptor Tie2. This receptor is essential for blood vessel formation and promotes endothelial survival. Here we examine the effects of ABIN-2 on endothelial cell apoptosis and its potential involvement in Tie2-mediated endothelial survival. ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. The inhibitors of phosphatidylinositol-3 kinase, wortmannin and LY294002, suppressed ABIN-2 inhibition of endothelial cell death. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis. Expression of truncated ABIN-2 prevented the Tie2-activating ligand angiopoietin-1 from inhibiting endothelial cell death. (Blood. 2003;102:4407-4409) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. P.J. Brindle, P. Saharinen, and K. Alitalo Signaling and Functions of Angiopoietin-1 in Vascular Protection Circ. Res., April 28, 2006; 98(8): 1014 - 1023. [Abstract] [Full Text] [PDF] T. Murakami, H. Takagi, K. Suzuma, I. Suzuma, H. Ohashi, D. Watanabe, T. Ojima, E. Suganami, M. Kurimoto, H. Kaneto, et al. Angiopoietin-1 Attenuates H2O2-induced SEK1/JNK Phosphorylation through the Phosphatidylinositol 3-Kinase/Akt Pathway in Vascular Endothelial Cells J. Biol. Chem., September 9, 2005; 280(36): 31841 - 31849. [Abstract] [Full Text] [PDF] Y. Arao, A. Kikuchi, M. Kishida, M. Yonekura, A. Inoue, S. Yasuda, S. Wada, K. Ikeda, and F. Kayama Stability of A+U-Rich Element Binding Factor 1 (AUF1)-Binding Messenger Ribonucleic Acid Correlates with the Subcellular Relocalization of AUF1 in the Rat Uterus upon Estrogen Treatment Mol. Endocrinol., September 1, 2004; 18(9): 2255 - 2267. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020