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Prepublished online as a Blood First Edition Paper on March 27, 2003; DOI 10.1182/blood-2002-09-2966. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-09-2966v1 102/2/585    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sun, C.-M. Articles by Lo-Man, R. Search for Related Content PubMed PubMed Citation Articles by Sun, C.-M. Articles by Lo-Man, R. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 July 2003, Vol. 102, No. 2, pp. 585-591 IMMUNOBIOLOGY Ontogeny and innate properties of neonatal dendritic cells Cheng-Ming Sun, Laurence Fiette, Myriam Tanguy, Claude Leclerc, and Richard Lo-Man From the Unité de Biologie des Régulations Immunitaires (Institut National de la Santé et de la Recherche Médicale [INSERM] E0352) and Unité de Recherche et d'Expertise en Histologie et Pathologie, Institut Pasteur, Paris, France We investigated whether a developmental immaturity of the dendritic cells (DCs) compartment could contribute to the high susceptibility to infections observed in newborns. DCs are among the first cells to colonize the spleen, but the ontogeny of DC subsets follows distinct steps. At birth, plasmacytoid DCs and CD4-CD8- DCs are found in the spleen, whereas CD8+ and CD4+ DCs are not present. Then, the CD8+ DC compartment quickly develops and reaches an adult size by day 7, whereas the CD4+ DC compartment slowly increases to become predominant by the age of 3 weeks. The production of interleukin (IL)–12p70 by DCs is particularly efficient after birth, reflecting the stronger capacity of the neonatal CD8- DCs to secrete IL-12 compared with its adult counterpart. Like-wise, neonatal DCs produced type I and II interferons. In vivo, following microbial stimulation, up-regulation of major histocompatibility complexes (MHCs) and of costimulatory molecules on DCs was induced clearly showing the activation of neonatal DCs in the neonatal environment. Therefore, despite a markedly different DC subset composition in early life compared with the adult DC compartment, neonatal DCs are fully competent in their innate immune functions. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H.-H. Lee, C. M. 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