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 Prepublished online as a Blood First Edition Paper on March 20, 2003; DOI 10.1182/blood-2002-10-3186.

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Blood, 15 July 2003, Vol. 102, No. 2, pp. 601-604

IMMUNOBIOLOGY

CD8{alpha}+ mouse spleen dendritic cells do not originate from the CD8{alpha}- dendritic cell subset

Shalin Naik, David Vremec, Li Wu, Meredith O'Keeffe, and Ken Shortman

From The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Melbourne, Victoria, Australia

Although previous studies had indicated that the CD8{alpha}- and CD8{alpha}+ subtypes of murine dendritic cells (DCs) differ in immediate origin, a recent study found that intravenous transfer of CD8{alpha}- DCs led to CD8{alpha}+ DCs in the spleen several days later, suggesting a direct precursor-product relationship. We have repeated these experiments with a balance sheet approach. We find that though a few CD8{alpha}+ DCs can be generated in such experiments, this is a rare event and could be the result of a contaminant precursor. Most of the immediate precursors of CD8{alpha}+ DCs are cells that lack the phenotype of a recognizable DC. CD8{alpha}- DCs and CD8{alpha}+ DCs are not precursor-product related, though these sublineages may be connected further upstream.


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