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Prepublished online as a Blood First Edition Paper on April 10, 2003; DOI 10.1182/blood-2002-11-3574. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-11-3574v1 102/3/1042    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tracey, L. Articles by Piris, M. A. Search for Related Content PubMed PubMed Citation Articles by Tracey, L. Articles by Piris, M. A. Related Collections Neoplasia Apoptosis Oncogenes and Tumor Suppressors Signal Transduction Gene Expression Genomics Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 August 2003, Vol. 102, No. 3, pp. 1042-1050 NEOPLASIA Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study Lorraine Tracey, Raquel Villuendas, Ana Maria Dotor, Inmaculada Spiteri, Pablo Ortiz, Juan F. García, Jose Luis Rodríguez Peralto, Mark Lawler, and Miguel A. Piris From the Centro Nacional de Investigaciones Oncológicas, Molecular Pathology Program, Madrid, Spain; the Pathology Department, Hospital Universitario de Getafe, Madrid, Spain; the Department of Hematology and the Institute for Molecular Medicine, St James Hospital, Dublin, Ireland; and the Dermatology and Pathology Department, Hospital 12 de Octubre, Madrid, Spain, representing the Cooperative Cutaneous Lymphoma Group of Madrid Mycosis fungoides (MF) is the most frequent type of cutaneous T-cell lymphoma, whose diagnosis and study is hampered by its morphologic similarity to inflammatory dermatoses (ID) and the low proportion of tumoral cells, which often account for only 5% to 10% of the total tissue cells. cDNA microarray studies using the CNIO OncoChip of 29 MF and 11 ID cases revealed a signature of 27 genes implicated in the tumorigenesis of MF, including tumor necrosis factor receptor (TNFR)–dependent apoptosis regulators, STAT4, CD40L, and other oncogenes and apoptosis inhibitors. Subsequently a 6-gene prediction model was constructed that is capable of distinguishing MF and ID cases with unprecedented accuracy. This model correctly predicted the class of 97% of cases in a blind test validation using 24 MF patients with low clinical stages. Unsupervised hierarchic clustering has revealed 2 major subclasses of MF, one of which tends to include more aggressive-type MF cases including tumoral MF forms. Furthermore, signatures associated with abnormal immunophenotype (11 genes) and tumor stage disease (5 genes) were identified. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: A profile of mycosis fungoides David M. Dorfman Blood 2003 102: 778. [Full Text] [PDF] This article has been cited by other articles: E. Caprini, C. Cristofoletti, D. Arcelli, P. Fadda, M. H. Citterich, F. Sampogna, A. Magrelli, F. Censi, P. Torreri, M. Frontani, et al. 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