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Prepublished online as a Blood First Edition Paper on April 10, 2003; DOI 10.1182/blood-2003-01-0091. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-01-0091v1 102/3/814    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Giebel, S. Articles by Holowiecki, J. Search for Related Content PubMed PubMed Citation Articles by Giebel, S. Articles by Holowiecki, J. Related Collections Immunobiology Transplantation Clinical Trials and Observations Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 August 2003, Vol. 102, No. 3, pp. 814-819 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors Sebastian Giebel, Franco Locatelli, Teresa Lamparelli, Andrea Velardi, Stella Davies, Guido Frumento, Rita Maccario, Federico Bonetti, Jerzy Wojnar, Miryam Martinetti, Francesco Frassoni, Giovanna Giorgiani, Andrea Bacigalupo, and Jerzy Holowiecki From the Department of Haematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland; Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy; Divisione di Ematologia II, Ospedale S. Martino, Genova, Italy; Department of Clinical and Experimental Medicine, Division of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy; Blood and Marrow Transplant Program, University of Minnesota, Minneapolis; Laboratorio di Immunogenetica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy; and Servizio di Immunoematologia e Trasfusione, Centro di Immunologia dei Trapianti, IRCCS Policlinico San Matteo, Pavia, Italy Killer immunoglobulin-like receptor (KIR) ligand incompatibility in the graft-versus-host direction was demonstrated to be associated with improved outcome in patients given haploidentical, T-cell–depleted hematopoietic stem cell transplants (HSCTs). The goal of this study was to evaluate whether that observation could be generalized for patients receiving unmanipulated HSCTs from unrelated donors (URD). One hundred thirty patients with hematologic malignancies entered the study. Graft-versus-host disease (GVHD) prophylaxis was uniform and consisted of cyclosporin, short-term methotrexate, and pretransplantation antithymocyte globulin (ATG). Patients were divided into those with (n = 20) and those without (n = 110) KIR ligand incompatibility with respect to their donors. At 4.5 years patients with KIR ligand incompatibility had higher probability of overall survival (87% versus 48%, P = .006) and disease-free survival (87% versus 39%, P = .0007) compared with those without KIR ligand incompatibility. Transplant-related mortality for the 2 groups equaled 6% and 40% (P = .01), respectively. Relapse rates for patients receiving transplants from a donor with or without KIR ligand incompatibility were 6% and 21%, respectively (P = .07). All patients with myeloid malignancies receiving transplants from KIR ligand–disparate donors (n = 13) are alive and disease free. These data indicate that natural killer (NK) cell alloreactivity is associated with better outcome after URD-HSC transplantation when ATG is used as part of GVHD prophylaxis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors Martin Bornhäuser, Rainer Schwerdtfeger, Hilmar Martin, Karl-Heinz Frank, Catrin Theuser, Gerhard Ehninger, Franco Locatelli, Andrea Velardi, and Sebastian Giebel Blood 2004 103: 2860-2861. [Full Text] [PDF] This article has been cited by other articles: F. Romagne, P. Andre, P. Spee, S. Zahn, N. Anfossi, L. Gauthier, M. Capanni, L. Ruggeri, D. M. Benson Jr, B. W. Blaser, et al. Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells Blood, September 24, 2009; 114(13): 2667 - 2677. 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