Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Prepublished online as a Blood First Edition Paper on May 8, 2003; DOI 10.1182/blood-2002-11-3337.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2002-11-3337v1
102/5/1915    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barker, J. N.
Right arrow Articles by Wagner, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barker, J. N.
Right arrow Articles by Wagner, J. E.
Related Collections
Right arrow Immunobiology
Right arrow Neoplasia
Right arrow Transplantation
Right arrow Clinical Trials and Observations
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Blood, 1 September 2003, Vol. 102, No. 5, pp. 1915-1919

TRANSPLANTATION

Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning

Juliet N. Barker, Daniel J. Weisdorf, Todd E. DeFor, Bruce R. Blazar, Jeffrey S. Miller, and John E. Wagner

From the Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN.

Reduced-intensity conditioning may reduce transplantation-related mortality in high-risk adults undergoing hematopoietic transplantation. We investigated unrelated donor umbilical cord blood (UCB) transplantation after such conditioning in 43 patients (median age, 49.5 years; range, 22-65 years) with a primary end point of donor engraftment. The first 21 patients received busulfan 8 mg/kg, fludarabine 200 mg/m2, and 200 cGy of total body irradiation (Bu/Flu/TBI). Subsequent patients (n = 22) received cyclophosphamide 50 mg/kg, fludarabine 200 mg/m2, and 200 cGy TBI (Cy/Flu/TBI). UCB grafts (93%) were 1-2 HLA antigen–mismatched with the recipient and contained a median cryopreserved cell dose of 3.7 x 107 (range, 1.6 x 107-6.0 x 107) nucleated cells per kilogram of recipient body weight (NC/kg). Graft versus host disease (GVHD) prophylaxis was cyclosporin A to day 180 plus mycophenolate mofetil to day 30. The cumulative incidence of sustained donor engraftment was 76% (95% confidence interval [CI], 56%-96%) for Bu/Flu/TBI recipients and 94% (95% CI, 84%-100%) for Cy/Flu/TBI recipients. The median day of neutrophil recovery (at least 0.5 x 109/L) for engrafting Bu/Flu/TBI recipients was 26 days (range, 12-30 days) and for Cy/Flu/TBI recipients was 9.5 days (range, 5-28 days). Incidence of grades III-IV acute GVHD was 9% (95% CI, 1%-17%), and survival at 1 year was 39% (95% CI, 23%-56%). These data demonstrate that 0-2 antigen mismatched UCB is sufficient to engraft most adults after reduced-intensity conditioning and is associated with a low incidence of severe acute GVHD.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
N. Matsuno, A. Wake, N. Uchida, K. Ishiwata, H. Araoka, S. Takagi, M. Tsuji, H. Yamamoto, D. Kato, Y. Matsuhashi, et al.
Impact of HLA disparity in the graft-versus-host direction on engraftment in adult patients receiving reduced-intensity cord blood transplantation
Blood, August 20, 2009; 114(8): 1689 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. H. Salinger, D. K. Blough, P. Vicini, C. Anasetti, P. V. O'Donnell, B. M. Sandmaier, and J. S. McCune
A Limited Sampling Schedule to Estimate Individual Pharmacokinetic Parameters of Fludarabine in Hematopoietic Cell Transplant Patients
Clin. Cancer Res., August 15, 2009; 15(16): 5280 - 5287.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. G. Brunstein, J. E. Wagner, D. J. Weisdorf, S. Cooley, H. Noreen, J. N. Barker, T. DeFor, M. R. Verneris, B. R. Blazar, and J. S. Miller
Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity
Blood, May 28, 2009; 113(22): 5628 - 5634.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. L. MacMillan, D. J. Weisdorf, C. G. Brunstein, Q. Cao, T. E. DeFor, M. R. Verneris, B. R. Blazar, and J. E. Wagner
Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors
Blood, March 12, 2009; 113(11): 2410 - 2415.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
L. J. Giassi, T. Pearson, L. D. Shultz, J. Laning, K. Biber, M. Kraus, B. A. Woda, M. R. Schmidt, R. T. Woodland, A. A. Rossini, et al.
Expanded CD34+ Human Umbilical Cord Blood Cells Generate Multiple Lymphohematopoietic Lineages in NOD-scid IL2r{gamma}null Mice
Experimental Biology and Medicine, August 1, 2008; 233(8): 997 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
F. R. Appelbaum
Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia When a Matched Related Donor Is Not Available
Hematology, January 1, 2008; 2008(1): 412 - 417.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. G. Brunstein, J. N. Barker, D. J. Weisdorf, T. E. DeFor, J. S. Miller, B. R. Blazar, P. B. McGlave, and J. E. Wagner
Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease
Blood, October 15, 2007; 110(8): 3064 - 3070.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. S. Tallman, G. W. Dewald, S. Gandham, B. R. Logan, A. Keating, H. M. Lazarus, M. R. Litzow, J. Mehta, T. Pedersen, W. S. Perez, et al.
Impact of cytogenetics on outcome of matched unrelated donor hematopoietic stem cell transplantation for acute myeloid leukemia in first or second complete remission
Blood, July 1, 2007; 110(1): 409 - 417.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
J. H. Antin
Reduced-Intensity Stem Cell Transplantation: "...whereof a little More than a little is by much too much." King Henry IV, part 1, I, 2
Hematology, January 1, 2007; 2007(1): 47 - 54.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
J. N. Barker
Umbilical Cord Blood (UCB) Transplantation: An Alternative to the Use of Unrelated Volunteer Donors?
Hematology, January 1, 2007; 2007(1): 55 - 61.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
Section on Hematology/Oncology and Section on Alle
Cord Blood Banking for Potential Future Transplantation
Pediatrics, January 1, 2007; 119(1): 165 - 170.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. G. Brunstein, D. J. Weisdorf, T. DeFor, J. N. Barker, J. Tolar, J.-A. H. van Burik, and J. E. Wagner
Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantation
Blood, October 15, 2006; 108(8): 2874 - 2880.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. S. Majhail, D. J. Weisdorf, J. E. Wagner, T. E. Defor, C. G. Brunstein, and L. J. Burns
Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma
Blood, May 1, 2006; 107(9): 3804 - 3807.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
N. J. Chao
Umbilical Cord Blood: Biology and Transplantation
Am. Assoc. Cancer Res. Educ. Book, April 1, 2006; 2006(1): 329 - 333.
[Full Text] [PDF]

Home page
 BloodHome page
K. K. Ballen
New trends in umbilical cord blood transplantation
Blood, May 15, 2005; 105(10): 3786 - 3792.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. N. Fernandez, C. Regidor, R. Cabrera, G. Bandini, F. Bonifazi, M. Stanzani, M. J. Laughlin, M. Eapen, P. Rubinstein, V. Rocha, et al.
Umbilical-Cord Blood for Transplantation in Adults
N. Engl. J. Med., March 3, 2005; 352(9): 935 - 937.
[Full Text] [PDF]

Home page
 ASH Education BookHome page
W. Tse and M. J. Laughlin
Umbilical Cord Blood Transplantation: A New Alternative Option
Hematology, January 1, 2005; 2005(1): 377 - 383.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
M. Kami, A. Makimoto, Y. Heike, and Y. Takaue
Reduced-intensity Hematopoietic Stem Cell Transplantation (RIST) for Solid Malignancies
Jpn. J. Clin. Oncol., December 1, 2004; 34(12): 707 - 716.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Kosaka, K. Koh, N. Kinukawa, Y. Wakazono, K. Isoyama, T. Oda, Y. Hayashi, S. Ohta, H. Moritake, M. Oda, et al.
Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantation
Blood, December 1, 2004; 104(12): 3527 - 3534.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Ichinohe, T. Uchiyama, C. Shimazaki, K. Matsuo, S. Tamaki, M. Hino, A. Watanabe, M. Hamaguchi, S. Adachi, H. Gondo, et al.
Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism
Blood, December 1, 2004; 104(12): 3821 - 3828.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. J. Laughlin, M. Eapen, P. Rubinstein, J. E. Wagner, M.-J. Zhang, R. E. Champlin, C. Stevens, J. N. Barker, R. P. Gale, H. M. Lazarus, et al.
Outcomes after Transplantation of Cord Blood or Bone Marrow from Unrelated Donors in Adults with Leukemia
N. Engl. J. Med., November 25, 2004; 351(22): 2265 - 2275.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Miyakoshi, K. Yuji, M. Kami, E. Kusumi, Y. Kishi, K. Kobayashi, N. Murashige, T. Hamaki, S.-W. Kim, J.-i. Ueyama, et al.
Successful Engraftment After Reduced-Intensity Umbilical Cord Blood Transplantation for Adult Patients with Advanced Hematological Diseases
Clin. Cancer Res., June 1, 2004; 10(11): 3586 - 3592.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Ooi, T. Iseki, S. Takahashi, A. Tomonari, K. Takasugi, Y. Shimohakamada, T. Yamada, K. Ishii, N. Ohno, F. Nagamura, et al.
Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia
Blood, January 15, 2004; 103(2): 489 - 491.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
N. J. Chao, S. G. Emerson, and K. I. Weinberg
Stem Cell Transplantation (Cord Blood Transplants)
Hematology, January 1, 2004; 2004(1): 354 - 371.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. A. Kaminski, S. Kadereit, R. E. Miller, P. Leahy, K. R. Stein, D. A. Topa, T. Radivoyevitch, M. L. Veigl, and M. J. Laughlin
Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation
Blood, December 15, 2003; 102(13): 4608 - 4617.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020