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Prepublished online as a Blood First Edition Paper on June 5, 2003; DOI 10.1182/blood-2002-11-3572. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-11-3572v1 102/6/2165    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zhang, Y. Articles by Paige, C. J. Search for Related Content PubMed PubMed Citation Articles by Zhang, Y. Articles by Paige, C. J. Related Collections Immunobiology Apoptosis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 September 2003, Vol. 102, No. 6, pp. 2165-2172 IMMUNOBIOLOGY T-cell developmental blockage by tachykinin antagonists and the role of hemokinin 1 in T lymphopoiesis Yu Zhang, and Christopher J. Paige From the Ontario Cancer Institute, Princess Margaret Hospital, University Health Network and Department of Medical Biophysics and Immunology, University of Toronto, Ontario, Canada. Hemokinin 1 (HK-1) is a new member of the tachykinin peptide family that is expressed in hematopoietic cells. Recent reports studying mouse, rat, and human orthologs of HK-1 demonstrate a broader distribution than originally reported. Our previous studies demonstrated that HK-1, by promoting proliferation, survival, and possibly maturation of B-cell precursors, plays an important role in B lymphopoiesis. Here we present data showing that HK-1 also influences T-cell development at a similar stage of differentiation. This peptide enhanced the proliferation of T-cell precursors and increased the number of thymocytes in fetal thymus organ cultures (FTOCs). Tachykinin antagonists, on the other hand, greatly reduced the cellularity of thymi both in vivo and in vitro. The major reduction occurred in the CD4/CD8 double-positive (DP) cells and the CD44–CD25+ subset of the CD4/CD8 double-negative (DN) cells. Of note, these populations also express HK-1, raising the possibility of autocrine or paracrine pathways influencing T-cell development as we previously reported for B-cell development. Consistent with this, the detrimental effect of tachykinin antagonists could be partially overcome with exogenous HK-1 peptide. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. M. Janelsins, A. R. Mathers, O. A. Tkacheva, G. Erdos, W. J. Shufesky, A. E. Morelli, and A. T. Larregina Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity Blood, March 26, 2009; 113(13): 3017 - 3026. [Abstract] [Full Text] [PDF] M. Nowicki, D. Ostalska-Nowicka, B. Kondraciuk, and B. Miskowiak The significance of substance P in physiological and malignant haematopoiesis J. Clin. Pathol., July 1, 2007; 60(7): 749 - 755. [Abstract] [Full Text] [PDF] D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev, October 1, 2006; 86(4): 1309 - 1379. [Abstract] [Full Text] [PDF] G. J. Graham, J. M. Stevens, N. M. Page, A. D. Grant, S. D. Brain, P. J. Lowry, and J. M. Gibbins Tachykinins regulate the function of platelets Blood, August 15, 2004; 104(4): 1058 - 1065. [Abstract] [Full Text] [PDF]

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