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Blood, 15 October 2003, Vol. 102, No. 8, pp. 2994-3002. Prepublished online as a Blood First Edition Paper on June 26, 2003; DOI 10.1182/blood-2003-01-0045. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-01-0045v1 102/8/2994    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sanchez, M.-L. Articles by Orfao, A. Search for Related Content PubMed PubMed Citation Articles by Sanchez, M.-L. Articles by Orfao, A. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Incidence and clinicobiologic characteristics of leukemic B-cell chronic lymphoproliferative disorders with more than one B-cell clone Maria-Luz Sanchez, Julia Almeida, David Gonzalez, Marcos Gonzalez, Maria-Antonia Garcia-Marcos, Ana Balanzategui, Maria-Consuelo Lopez-Berges, Josep Nomdedeu, Teresa Vallespi, Marcos Barbon, Alejandro Martin, Pilar de la Fuente, Guillermo Martin-Nuñez, Javier Fernandez-Calvo, Jesus-Maria Hernandez, Jesus F. San Miguel, and Alberto Orfao From the Servicio General de Citometria y Departamento de Medicina, Universidad de Salamanca; Centro de Investigacion del Cancer, Universidad de Salamanca; Servicio de Hematologia, Hospital Universitario de Salamanca; Servicio de Hematologia, Hospital Santa Creu i Sant Pau, Barcelona; Servicio de Hematologia, Hospital Valle del Hebron, Barcelona; Servicio de Hematologia, Hospital Virgen Blanca, Leon; Servicio de Hematologia, Hospital Virgen de la Concha, Zamora; Servicio de Hematologia, Hospital General Yague, Burgos; Servicio de Hematologia, Hospital Virgen del Puerto, Plasencia; and Servicio de Hematologia, Hospital Clínico de Valladolid, Spain. Leukemic B-chronic lymphoproliferative disorders (B-CLPDs) are generally believed to derive from a monoclonal B cell; biclonality has only occasionally been reported. In this study, we have explored the incidence of B-CLPD cases with 2 or more B-cell clones and established both the phenotypic differences between the coexisting clones and the clinicobiologic features of these patients. In total, 53 B-CLPD cases with 2 or more B-cell clones were studied. Presence of 2 or more B-cell clones was suspected by immunophenotype and confirmed by molecular/genetic techniques in leukemic samples (n = 42) and purified B-cell subpopulations (n = 10). Overall, 4.8% of 477 consecutive B-CLPDs had 2 or more B-cell clones, their incidence being especially higher among hairy cell leukemia (3 of 13), large cell lymphoma (2 of 10), and atypical chronic lymphocytic leukemia (CLL) (4 of 29). In most cases the 2 B-cell subsets displayed either different surface immunoglobulin (sIg) light chain (n = 37 of 53) or different levels of the same sIg (n = 9 of 53), usually associated with other phenotypic differences. Compared with monoclonal cases, B-CLL patients with 2 or more clones had lower white blood cell (WBC) and lymphocyte counts, more frequently displayed splenomegaly, and required early treatment. Among these, the cases in which a CLL clone coexisted with a non-CLL clone were older and more often displayed B symptoms, a monoclonal component, and diffuse infiltration of bone marrow and required early treatment more frequently than cases with monoclonal CLL or 2 CLL clones. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. A. Hernandez, A. E. Rodriguez, M. Gonzalez, R. Benito, C. Fontanillo, V. Sandoval, M. Romero, G. Martin-Nunez, A. G. de Coca, R. Fisac, et al. A high number of losses in 13q14 chromosome band is associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemia Haematologica, March 1, 2009; 94(3): 364 - 371. [Abstract] [Full Text] [PDF] A. C. Rawstron, A. Orfao, M. Beksac, L. Bezdickova, R. A. Brooimans, H. Bumbea, K. Dalva, G. Fuhler, J. Gratama, D. Hose, et al. Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders Haematologica, March 1, 2008; 93(3): 431 - 438. [Abstract] [Full Text] [PDF] J. Kriangkum, B. J. Taylor, S. P. Treon, M. J. Mant, T. Reiman, A. R. Belch, and L. M. Pilarski Molecular Characterization of Waldenstrom's Macroglobulinemia Reveals Frequent Occurrence of Two B-Cell Clones Having Distinct IgH VDJ Sequences Clin. Cancer Res., April 1, 2007; 13(7): 2005 - 2013. [Abstract] [Full Text] [PDF] R. Gniadecki Neoplastic Stem Cells in Cutaneous Lymphomas: Evidence and Clinical Implications Arch Dermatol, September 1, 2004; 140(9): 1156 - 1160. [Full Text] [PDF]

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