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Blood, 1 November 2003, Vol. 102, No. 9, pp. 3083. This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Blood Work Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  BLOOD WORK Oxidant hemolysis Stanley Schrier, Stanford University Medical Center   [View Larger Version of this Image (111K GIF file)] The lefthand panel is a peripheral smear from a patient who developed a hemolytic anemia while taking Pyridium (phenazopyridine). She was supposed to take it for 3 days for bladder discomfort but continued taking it for almost a month. Note the "bite cells," which are abnormal red blood cells (RBCs) that look like a bite has been taken out; other names are hemiblister or cross-linked cells. The drug causes oxidant damage to the RBC membrane and hemoglobin, leading to accelerated removal of the affected RBCs. The righthand panel is a positive Heinz-body preparation from the patient. The supravital stain of the peripheral blood with new methyl violet detects oxidatively denatured hemoglobin. Splenic removal (pitting) of the denatured hemoglobin may produce the "bites" seen in the first panel.   The above image was first published in the ASH IMAGE BANK, a reference and teaching tool that is continually updated with new atlas images and images of case studies. For more information or to contribute to the Image Bank, visit ashimagebank.hematologylibrary.org. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Blood Work Social Bookmarking                   What's this?

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