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Blood, 1 January 2004, Vol. 103, No. 1, pp. 13-19. Prepublished online as a Blood First Edition Paper on September 4, 2003; DOI 10.1182/blood-2003-05-1684. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-05-1684v1 103/1/13    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bailey, A. S. Articles by Fleming, W. H. Search for Related Content PubMed PubMed Citation Articles by Bailey, A. S. Articles by Fleming, W. H. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Plenary Papers Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PLENARY PAPERS Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells Alexis S. Bailey, Shuguang Jiang, Michael Afentoulis, Christina I. Baumann, David A. Schroeder, Susan B. Olson, Melissa H. Wong, and William H. Fleming From the Bone Marrow Transplantation (BMT) Program, Division of Hematology and Medical Oncology, Division of Cardiology Department of Medicine, Department of Molecular and Medical Genetics, and Department of Dermatology, Oregon Health & Science University, Portland, OR. During early embryogenesis, blood vessels and hematopoietic cells arise from a common precursor cell, the hemangioblast. Recent studies have identified endothelial progenitor cells in the peripheral blood, and there is accumulating evidence that a subset of these cells is derived from precursors in the bone marrow. Here we show that adult bone marrow–derived, phenotypically defined hematopoietic stem cells (c-kit+, Sca-1+, lineage–) give rise to functional endothelial cells. With the exception of the brain, donor-derived cells are rapidly integrated into blood vessels. Durably engrafted endothelial cells express CD31, produce von Willebrand factor, and take up low-density lipoprotein. Analysis of DNA content indicates that donor-derived endothelial cells are not the products of cell fusion. Self-renewal of stem cells with hematopoietic and endothelial cell potential was revealed by serial transplantation studies. The clonal origin of both hematopoietic and endothelial cell outcomes was established by the transfer of a single cell. These results suggest that adult bone marrow–derived hematopoietic stem cells may serve as a reservoir for endothelial cell progenitors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Hemangioblasts in adults? Margaret H. Baron Blood 2004 103: 1. [Full Text] [PDF] This article has been cited by other articles: D. C. Goldman, A. S. Bailey, D. L. Pfaffle, A. Al Masri, J. L. Christian, and W. H. Fleming BMP4 regulates the hematopoietic stem cell niche Blood, November 12, 2009; 114(20): 4393 - 4401. [Abstract] [Full Text] [PDF] D. P Sieveking and M. K. Ng Cell therapies for therapeutic angiogenesis: back to the bench Vascular Medicine, May 1, 2009; 14(2): 153 - 166. [Abstract] [PDF] J. A. Fritzell Jr., Q. Mao, S. Gundavarapu, T. Pasquariello, J. M. Aliotta, A. Ayala, J. F. Padbury, and M. E. De Paepe Fate and Effects of Adult Bone Marrow Cells in Lungs of Normoxic and Hyperoxic Newborn Mice Am. J. Respir. Cell Mol. 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