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Blood, 1 January 2004, Vol. 103, No. 1, pp. 360-362. Prepublished online as a Blood First Edition Paper on July 24, 2003; DOI 10.1182/blood-2003-06-1843. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-06-1843v1 103/1/360    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Meignin, V. Articles by Socié, G. Search for Related Content PubMed PubMed Citation Articles by Meignin, V. Articles by Socié, G. Related Collections Hematopoiesis and Stem Cells Immunobiology Transplantation Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief report Little evidence of donor-derived epithelial cells in early digestive acute graft-versus-host disease Véronique Meignin, Jean Soulier, Frédéric Brau, Marc Lemann, Eliane Gluckman, Anne Janin, and Gérard Socié From Institut National de la Santé et de la Recherche Médicale (INSERM) ERM-0220, Service de Pathologie, Laboratoire central d'Hématologie, Service Commun d'Imagerie Moléculaire et Cellulaire, Service d'HépatoGastroentérologie, and Service d'Hématologie/Greffe de Moelle, Institut Universitaire d'Hématologie, Université Paris VII, Hôpital Saint Louis, AP-HP, Paris, France. Donor origin of epithelial intestinal cells has been studied in animals and humans after transplantation and has been used as evidence of hematopoietic stem cell (HSC) plasticity. However, in the human gastrointestinal tract, no study used X- or Y-chromosome detection by fluorescence in situ hybridization (FISH) coupled with immunologic stainings to characterize cell types on the same tissue section. Here, we combined these techniques on the same section of duodenal epithelium in 6 patients with acute graft-versus-host disease. Donor-derived lymphoid cells were detected in the epithelium and the lamina propria, as expected. However, using our stringent criteria, no donor-derived cells could be proven to be epithelial. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. C.W. Hung, T. K.F. Shing, S. S.C. Chim, P. C. Yeung, R. W.Y. Chan, K. W. Chik, V. Lee, N. B.Y. Tsui, C.-K. Li, C. S.C. Wong, et al. Presence of Donor-Derived DNA and Cells in the Urine of Sex-Mismatched Hematopoietic Stem Cell Transplant Recipients: Implication for the Transrenal Hypothesis Clin. Chem., April 1, 2009; 55(4): 715 - 722. [Abstract] [Full Text] [PDF] A. Janin, H. Murata, C. Leboeuf, J.-M. Cayuela, E. Gluckman, L. Legres, A. Desveaux, M. Varna, P. Ratajczak, J. Soulier, et al. Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation Blood, February 19, 2009; 113(8): 1834 - 1840. [Abstract] [Full Text] [PDF] D. Imanishi, Y. Miyazaki, R. Yamasaki, Y. Sawayama, J. Taguchi, H. Tsushima, T. Fukushima, S. Yoshida, H. Sasaki, T. Hata, et al. Donor-derived DNA in fingernails among recipients of allogeneic hematopoietic stem-cell transplants Blood, October 1, 2007; 110(7): 2231 - 2234. [Abstract] [Full Text] [PDF] H. Murata, A. Janin, C. Leboeuf, J. Soulier, E. Gluckman, V. Meignin, and G. Socie Donor-derived cells and human graft-versus-host disease of the skin Blood, March 15, 2007; 109(6): 2663 - 2665. [Abstract] [Full Text] [PDF]

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