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Blood, 15 May 2004, Vol. 103, No. 10, pp. 3964-3969. Prepublished online as a Blood First Edition Paper on January 22, 2004; DOI 10.1182/blood-2003-10-3697. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-10-3697v1 103/10/3964    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lan, P. Articles by Yang, Y.-G. Search for Related Content PubMed PubMed Citation Articles by Lan, P. Articles by Yang, Y.-G. Related Collections Hematopoiesis and Stem Cells Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism Ping Lan, Lan Wang, Bintou Diouf, Hiroshi Eguchi, Hui Su, Roderick Bronson, David H. Sachs, Megan Sykes, and Yong-Guang Yang From the Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Xenotransplantation from pigs could provide a potential solution to the severe shortage of allogeneic donor organs. Because xenogeneic tissues are subject to vigorous immune rejection, tolerance induction is likely to be essential to the success of clinical xenotransplantation. Here we explore the possibility of inducing human T-cell tolerance to porcine xenografts through mixed chimerism. We previously showed that NOD/SCID-Tg mice expressing porcine cytokine transgenes permit the induction of durable porcine hematopoietic chimerism. In this study we achieved human T-cell development in these mice by engrafting human fetal thymus/liver tissues. In porcine hematopoietic chimeras, human thymus grafts were populated with porcine class IIhigh cells in addition to human cells, and human T cells were tolerant of the porcine hematopoietic donor as measured by mixed lymphocyte reaction assay and skin grafting. This study proves the principle that porcine chimerism induces tolerance of xenoreactive human T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Li, Y. Yan, Y. Lin, D. M. Bullens, O. Rutgeerts, J. Goebels, C. Segers, L. Boon, A. Kasran, R. De Vos, et al. Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells Blood, December 1, 2007; 110(12): 3926 - 3935. [Abstract] [Full Text] [PDF] K. Ide, H. Wang, H. Tahara, J. Liu, X. Wang, T. Asahara, M. Sykes, Y.-G. Yang, and H. Ohdan Role for CD47-SIRP{alpha} signaling in xenograft rejection by macrophages PNAS, March 20, 2007; 104(12): 5062 - 5066. [Abstract] [Full Text] [PDF] H. Wang, J. VerHalen, M. L. Madariaga, S. Xiang, S. Wang, P. Lan, P.-A. Oldenborg, M. Sykes, and Y.-G. Yang Attenuation of phagocytosis of xenogeneic cells by manipulating CD47 Blood, January 15, 2007; 109(2): 836 - 842. [Abstract] [Full Text] [PDF] P. Lan, N. Tonomura, A. Shimizu, S. Wang, and Y.-G. Yang Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation Blood, July 15, 2006; 108(2): 487 - 492. [Abstract] [Full Text] [PDF] W. Chen, D. Zhou, J. R. Torrealba, T. K. Waddell, D. Grant, and L. Zhang Donor Lymphocyte Infusion Induces Long-Term Donor-Specific Cardiac Xenograft Survival through Activation of Recipient Double-Negative Regulatory T Cells J. Immunol., September 1, 2005; 175(5): 3409 - 3416. [Abstract] [Full Text] [PDF]

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