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Blood, 15 May 2004, Vol. 103, No. 10, pp. 3986-3988. Prepublished online as a Blood First Edition Paper on February 5, 2004; DOI 10.1182/blood-2003-09-3286. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-09-3286v1 103/10/3986    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yamashita, K. Articles by Horwitz, M. E. Search for Related Content PubMed PubMed Citation Articles by Yamashita, K. Articles by Horwitz, M. E. Related Collections Immunobiology Transplantation Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief report Severe chronic graft-versus-host disease is characterized by a preponderance of CD4+ effector memory cells relative to central memory cells Kouhei Yamashita, Uimook Choi, Patricia C. Woltz, Susan F. Foster, Michael C. Sneller, Francis T. Hakim, Daniel H. Fowler, Michael R. Bishop, Steven Z. Pavletic, Marisa Tamari, Kathleen Castro, A. John Barrett, Richard W. Childs, Gabor G. Illei, Susan F. Leitman, Harry L. Malech, and Mitchell E. Horwitz From the Laboratory of Host Defenses and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD; Experimental Transplantation Immunology Branch, National Cancer Institute, NIH, Bethesda, MD; Hematology Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD; Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD; Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD; Duke University Medical Center, Bone Marrow Transplant Program, Durham, NC. Donor alloreactive CD4+ T cells are important to the pathogenesis of chronic graft-versus-host disease (cGVHD), but specific subsets of CD4+ T cells responsible for GVHD have not been defined. We hypothesized that cGVHD might be associated with a preponderance of CD4+ effector memory cells (CCR7–/CD62Llow, CD4EM). We analyzed CCR7 and CD62L expression on CD4+ T cells from stem cell transplantation patients, who did or did not develop cGVHD, and healthy donors. Patients with cGVHD had a higher percentage of CD4EM cells (35.5% ± 2.9%) than healthy donors (13.8% ± 0.7%; P < .0001) or patients without cGVHD that received a transplant (21.7% ± 2.1%; P < .01). Using corticosteroid dose as a surrogate marker for cGVHD severity, severe cGVHD was associated with a higher percentage of CD4EM cells. The proportion of CD4EM cells in corticosteroid-dependent patients with systemic lupus erythematosis or Wegener granulomatosis did not differ from patients without cGVHD that received a transplant. This finding implies that overrepresentation of CD4EM cells is a unique feature of cGVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Zhang, E. Hexner, D. Frank, and S. G. Emerson CD4+ T Cells Generated De Novo from Donor Hemopoietic Stem Cells Mediate the Evolution from Acute to Chronic Graft-versus-Host Disease J. Immunol., September 1, 2007; 179(5): 3305 - 3314. [Abstract] [Full Text] [PDF] A. Schmitz, A. Sankaranarayanan, P. Azam, K. Schmidt-Lassen, D. Homerick, W. Hansel, and H. Wulff Design of PAP-1, a Selective Small Molecule Kv1.3 Blocker, for the Suppression of Effector Memory T Cells in Autoimmune Diseases Mol. Pharmacol., November 1, 2005; 68(5): 1254 - 1270. [Abstract] [Full Text] [PDF] S. Z. Pavletic, S. L. Carter, N. A. Kernan, J. Henslee-Downey, A. M. Mendizabal, E. Papadopoulos, R. Gingrich, J. Casper, S. Yanovich, D. Weisdorf, et al. Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation Blood, November 1, 2005; 106(9): 3308 - 3313. [Abstract] [Full Text] [PDF] S. J. Lee New approaches for preventing and treating chronic graft-versus-host disease Blood, June 1, 2005; 105(11): 4200 - 4206. [Abstract] [Full Text] [PDF] M. Bagdaany, C. V. F. Batista, N. A. Valdez-Cruz, S. Somodi, R. C. R. de la Vega, A. F. Licea, Z. Varga, R. Gaspar, L. D. Possani, and G. Panyi Anuroctoxin, a New Scorpion Toxin of the {alpha}-KTx 6 Subfamily, Is Highly Selective for Kv1.3 over IKCa1 Ion Channels of Human T Lymphocytes Mol. Pharmacol., April 1, 2005; 67(4): 1034 - 1044. [Abstract] [Full Text] [PDF] Y. Zhang, G. Joe, E. Hexner, J. Zhu, and S. G. Emerson Alloreactive Memory T Cells Are Responsible for the Persistence of Graft-versus-Host Disease J. Immunol., March 1, 2005; 174(5): 3051 - 3058. [Abstract] [Full Text] [PDF] S. Damjanovich, R. Gaspar, and G. Panyi An Alternative to Conventional Immunosuppression: Small-Molecule Inhibitors of Kv1.3 Channels Mol. Interv., October 1, 2004; 4(5): 250 - 254. [Abstract] [Full Text] [PDF]

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